InterPro : IPR013201

Name  Proteinase inhibitor I29, cathepsin propeptide Short Name  Prot_inhib_I29
Type  Domain Description  This entry represents a peptidase inhibitor domain, which belongs to MEROPS peptidase inhibitor family I29. The domain is also found at the N terminus of a variety of peptidase precursors that belong to MEROPS peptidase subfamily C1A; these include cathepsin L, papain, and procaricain () []. It forms an alpha-helical domain that runs through the substrate-binding site, preventing access. Removal of this region by proteolytic cleavage results in activation of the enzyme. This domain is also found, in one or more copies, in a variety of cysteine peptidase inhibitors such as salarin [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR013128 Peptidase C1A Peptidase_C1A Family
IPR015644 Peptidase C1A, cathepsin K Peptidase_C1A_cathepsin-K Family
IPR015645 Peptidase C1A, placentally-expressed cathepsin Pept_C1A_placental-cathepsin Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Groves MR The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft. 1996 Structure 4 1193-203
Olonen A A new type of cysteine proteinase inhibitor--the salarin gene from Atlantic salmon (Salmo salar L.) and Arctic charr (Salvelinus alpinus). 2003 Biochimie 85 677-81



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)