InterPro : IPR013128

Name  Peptidase C1A Short Name  Peptidase_C1A
Type  Family Description  This group of cysteine peptidases belong to MEROPS peptidase family C1, sub-family C1A (papain family, clan CA). It includes proteins classed as non-peptidase homologues. These are have either been shown experimentally to lack peptidase activity or lack one or more of the active site residues. The papain family has a wide variety of activities, including broad-range (papain) and narrow-range endo-peptidases, aminopeptidases, dipeptidyl peptidases and enzymes with both exo- and endo-peptidase activity []. Members of the papain family are widespread, found in baculovirus [], eubacteria, yeast, and practically all protozoa, plants and mammals []. The proteins are typicallylysosomal or secreted, and proteolytic cleavage of the propeptide is required for enzyme activation, although bleomycin hydrolase is cytosolic in fungi and mammals []. Papain-like cysteine proteinases are essentially synthesised as inactive proenzymes (zymogens) with N-terminal propeptide regions. The activation process of these enzymes includes the removal of propeptide regions. The propeptide regions serve a variety of functions in vivo and in vitro. The pro-region is required for the proper folding of the newly synthesised enzyme, the inactivation of the peptidase domain and stabilisation of the enzyme against denaturing at neutral to alkaline pH conditions. Amino acid residues within the pro-region mediate their membrane association, and play a role in the transport of the proenzyme to lysosomes. Among the most notable features of propeptides is their ability to inhibit the activity of their cognate enzymes and that certain propeptides exhibit high selectivity for inhibition of the peptidases from which they originate [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

3 Child Features

Id Name Short Name Type
IPR015644 Peptidase C1A, cathepsin K Peptidase_C1A_cathepsin-K Family
IPR015643 Peptidase C1A, cathepsin B Peptidase_C1A_cathepsin-B Family
IPR015645 Peptidase C1A, placentally-expressed cathepsin Pept_C1A_placental-cathepsin Family

4 Contains

Id Name Short Name Type
IPR000668 Peptidase C1A, papain C-terminal Peptidase_C1A_C Domain
IPR013201 Proteinase inhibitor I29, cathepsin propeptide Prot_inhib_I29 Domain
IPR012599 Peptidase C1A, propeptide Propeptide_C1A Domain
IPR000169 Cysteine peptidase, cysteine active site Pept_cys_AS Active_site

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Rawlings ND Families of cysteine peptidases. 1994 Methods Enzymol 244 461-86
Rawlings ND Evolutionary families of peptidases. 1993 Biochem J 290 ( Pt 1) 205-18
Sebti SM Purification, characterization, and amino acid composition of rabbit pulmonary bleomycin hydrolase. 1987 Biochemistry 26 4213-9
Yamamoto Y Novel cysteine proteinase inhibitors homologous to the proregions of cysteine proteinases. 2002 Curr Protein Pept Sci 3 231-8



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)