InterPro : IPR008952

Name  Tetraspanin, EC2 domain Short Name  Tetraspanin_EC2
Type  Domain Description  Tetraspanins are a distinct family of proteins, containing four transmembrane domains: a small outer loop (EC1), a larger outer loop (EC2), a small inner loop (IL) and short cytoplasmic tails. They contain characteristic structural features, including 4-6 conserved extracellular cysteine residues, and polar residues within transmembrane domains. A fundamental role of tetraspanins appears to be organizing other proteins into a network of multimolecular membrane microdomains, sometimes called the `tetraspanin web'. Within this web there are primary complexes in which tetraspanins show robust, specific, and direct lateral associations with other proteins. The strong tendency of tetraspanins to associate with each other probably contributes to the assembly of a network of secondary interactions in which non-tetraspanin proteins are associated with each other via palmitoylated tetraspanins acting as linker proteins. In addition, the association of lipids, such as gangliosides and cholesterol, probably contributes to the assembly of even larger tetraspanin complexes, which have some lipid raft-like properties (e.g. resistance to solubilization in non-ionic detergents). Within the tetraspanin web, tetraspanin proteins can associate not only with integrins and other transmembrane proteins, but also with signalling enzymes such as protein kinase C and phosphatidylinositol-4 kinase. Thus, the tetraspanin web provides a mechanistic framework by which membrane protein signalling can be expanded into a lateral dimension [].This entry represents the EC2 domain from tetraspanins, consisting of 5 helices in an irregular disulphide-linked array which plays a role in form homodimerization.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

1 Child Features

Id Name Short Name Type
IPR028977 CD81 antigen, large extracellular loop domain CD81_LEL Domain

1 Contains

Id Name Short Name Type
IPR018498 Peripherin/rom-1, conserved site Peripherin/rom-1_CS Conserved_site

3 Found In

Id Name Short Name Type
IPR018499 Tetraspanin/Peripherin Tetraspanin/Peripherin Family
IPR000301 Tetraspanin Tetraspanin Family
IPR000830 Peripherin/rom-1 Peripherin/rom-1 Family

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Stipp CS Functional domains in tetraspanin proteins. 2003 Trends Biochem Sci 28 106-12



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)