InterPro : IPR002004

Name  Polyadenylate-binding protein/Hyperplastic disc protein Short Name  PABP_HYD
Type  Domain Description  The polyadenylate-binding protein (PABP) has a conserved C-terminal domain (PABC), which is also found in the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains () []. PABP recognises the 3' mRNA poly(A) tail and plays an essential role in eukaryotic translation initiation and mRNA stabilisation/degradation. PABC domains of PABP are peptide-binding domains that mediate PABP homo-oligomerisation and protein-protein interactions. In mammals, the PABC domain of PABP functions to recruit several different translation factors to the mRNA poly(A) tail [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4 PABP_1234 Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Deo RC X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. 2001 Proc Natl Acad Sci U S A 98 4414-9
Kozlov G Solution structure of the orphan PABC domain from Saccharomyces cerevisiae poly(A)-binding protein. 2002 J Biol Chem 277 22822-8

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)