InterPro : IPR004100

Name  ATPase, F1 complex alpha/beta subunit, N-terminal domain Short Name  ATPase_F1_a/bsu_N
Type  Domain Description  F-ATPases (also known as F1F0-ATPase, or H(+)-transporting two-sector ATPase) () are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane-embedded proton channel that is composed of at least 3 subunits (A-C), nine in mitochondria (A-G, F6, F8). Both the F1 and F0 complexes are rotary motors that are coupled back-to-back. In the F1 complex, the central gamma subunit forms the rotor inside the cylinder made of the alpha(3)beta(3) subunits, while in the F0 complex, the ring-shaped C subunits forms the rotor. The two rotors rotate in opposite directions, but the F0 rotor is usually stronger, using the force from the proton gradient to push the F1 rotor in reverse in order to drive ATP synthesis []. These ATPases can also work in reverse in bacteria, hydrolysing ATP to create a proton gradient.The structure of the alpha and beta subunits is almost identical. Each subunit consists of a N-terminal beta-barrel, a central domain containing the nucleotide-binding site and a C-terminal alpha bundle domain []. This entry represents the N-terminal domain, which forms a closed beta-barrel with Greek-key topology.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

11 Found In

Id Name Short Name Type
IPR005294 ATPase, F1 complex, alpha subunit ATPase_F1-cplx_asu Family
IPR005723 ATPase, V1 complex, subunit B ATPase_V1-cplx_bsu Family
IPR005722 ATPase, F1 complex, beta subunit ATPase_F1-cplx_bsu Family
IPR005725 ATPase, V1 complex, subunit A ATPase_V1-cplx_asu Family
IPR005714 ATPase, type III secretion system, FliI/YscN ATPase_T3SS_FliI/YscN Family
IPR005724 ATPase, A1 complex, beta subunit ATPase_A1-cplx_bsu Family
IPR005726 ATP synthase alpha chain, archaea ATPase_asu_arc Family
IPR013380 ATPase, type III secretion system, H+-transporting ATPase_T3SS_H-transp Family
IPR017691 ATP synthase subunit beta, bacterial and archaeal Alt_ATPase_F1_bsu Family
IPR017710 Alternate F1F0 ATPase, F1 subunit alpha Alt_ATPase_F1_asu Family
IPR022425 Flagellar export ATPase FliI, clade 2 FliI_clade2 Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Yasuda R Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase. 2001 Nature 410 898-904
Abrahams JP Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria. 1994 Nature 370 621-8

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)