InterPro : IPR014790

Name  MutL, C-terminal, dimerisation Short Name  MutL_C
Type  Domain Description  MutL and MutS are key components of the DNA repair machinery that corrects replication errors []. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signalling complex for repair. The N-terminal region of MutL contains the ATPase domain and the C-terminal is involved in dimerisation [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

2 Found In

Id Name Short Name Type
IPR002099 DNA mismatch repair protein family DNA_mismatch_repair_fam Family
IPR020667 DNA mismatch repair protein, MutL DNA_mismatch_repair_MutL Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Guarné A Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. 2004 EMBO J 23 4134-45
Modrich P Mismatch repair in replication fidelity, genetic recombination, and cancer biology. 1996 Annu Rev Biochem 65 101-33

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)