InterPro : IPR013507

Name  DNA mismatch repair protein, C-terminal Short Name  DNA_mismatch_repair_C
Type  Domain Description  This entry represents the C-terminal domain of DNA mismatch repair proteins, such as MutL. This domain functions in promoting dimerisation []. The dimeric MutL protein has a key function in communicating mismatch recognition by MutS to downstream repair processes. Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR002099 DNA mismatch repair protein family DNA_mismatch_repair_fam Family
IPR011186 DNA mismatch repair protein Mlh1/HexB DNA_mismatch_repair_MLH1/HexB Family
IPR020667 DNA mismatch repair protein, MutL DNA_mismatch_repair_MutL Family

1 Parent Features

Id Name Short Name Type
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup Ribosomal_S5_D2-typ_fold_subgr Domain

2 Publications

First Author Title Year Journal Volume Pages
Schofield MJ DNA mismatch repair: molecular mechanisms and biological function. 2003 Annu Rev Microbiol 57 579-608
Kosinski J Analysis of the quaternary structure of the MutL C-terminal domain. 2005 J Mol Biol 351 895-909



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)