InterPro : IPR003594

Name  Histidine kinase-like ATPase, C-terminal domain Short Name  HATPase_C
Type  Domain Description  This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [], heat shock protein HSP90 [, , ], phytochrome-like ATPases and DNA mismatch repair proteins. The fold of this domain consists of two layers, alpha/beta, which contains an 8-stranded mixed beta-sheet.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR020575 Heat shock protein Hsp90, N-terminal Hsp90_N Domain

2 Contains

Id Name Short Name Type
IPR019805 Heat shock protein Hsp90, conserved site Heat_shock_protein_90_CS Conserved_site
IPR014762 DNA mismatch repair, conserved site DNA_mismatch_repair_CS Conserved_site

26 Found In

Id Name Short Name Type
IPR001404 Heat shock protein Hsp90 family Hsp90_fam Family
IPR001241 DNA topoisomerase, type IIA Topo_IIA Family
IPR002099 DNA mismatch repair protein family DNA_mismatch_repair_fam Family
IPR011186 DNA mismatch repair protein Mlh1/HexB DNA_mismatch_repair_MLH1/HexB Family
IPR006290 Heavy metal sensor kinase CztS_silS_copS Family
IPR005740 DNA topoisomerase 4 subunit B, Gram-positive ParE Family
IPR011557 DNA gyrase, subunit B GyrB Family
IPR005737 DNA topoisomerase IV, subunit B, Gram-negative TopoIV_B_Gneg Family
IPR001294 Phytochrome Phytochrome Family
IPR012129 Phytochrome A/B/C/D/E Phytochrome_A-E Family
IPR014285 Nitrogen fixation negative regulator NifL N_fixation_neg-reg_NifL Family
IPR016380 Signal transduction histidine kinase, nitrate/nitrite-sensing Sig_transdc_His_kin_NarX/NarQ Family
IPR016381 Signal transduction histidine kinase, DegS Sig_transdc_His_kinase_DegS Family
IPR016781 Anti-sigma regulatory factor, PmgA, predicted Anti-sigma_regulat_PmgA_prd Family
IPR020667 DNA mismatch repair protein, MutL DNA_mismatch_repair_MutL Family
IPR014525 Signal transduction histidine kinase, hybrid-type, ethylene sensor Sig_transdc_His_kin_hyb_Et-sen Family
IPR005734 DNA topoisomerase VI, subunit B TopoVI_B Family
IPR017206 Signal transduction histidine kinase, hybrid-type, BC3207, predicted Sig_transdc_His_kin_hyb_BC3207 Family
IPR010193 Serine-protein kinase RsbW RsbW Family
IPR010194 Anti-sigma F factor Anti-sigma_F Family
IPR022510 Sortase system, histidine kinase Sortase_His-kinase Family
IPR017171 Signal transduction histidine kinase, MctS Sig_transdc_His_kinase_MctS Family
IPR017205 Signal transduction histidine kinase, ChrS Sig_transdc_His_kinase_ChrS Family
IPR017202 Sensor histidine kinase LiaS/VraS LiaS/VraS Family
IPR017204 Signal transduction histidine kinase, STH3221, predicted Sig_transdc_His_kin_STH3221 Family
IPR008358 Signal transduction histidine kinase/phosphatase, lantibiotic regulatory protein MprB Sig_transdc_His_kin/Pase_MprB Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Bellon S Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase. 2004 Antimicrob Agents Chemother 48 1856-64
Immormino RM Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone. 2004 J Biol Chem 279 46162-71
Roe SM The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). 2004 Cell 116 87-98
Wright L Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms. 2004 Chem Biol 11 775-85

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)