InterPro : IPR000555

Name  JAB1/MPN/MOV34 metalloenzyme domain Short Name  JAMM/MPN+_dom
Type  Domain Description  This domain is known as the MPN domain [], PAD-1-like domain [], JABP1 domain []or JAMM domain []. Proteins with this domain include proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. They are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes []. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are predicted to have a similar role [].The archaeal (H. volcanii) JAMM domain containing protein, HvJAMM1, cleaves ubiquitin-like small archaeal modifier proteins (SAMP1/2) from protein conjugates []. The bacterial JAMM domain containing protein QbsD from Pseudomonas fluorescens cleaves the C-terminal amino acid residues of the sulfur carrier protein QbsE prior to the formation of the carboxy-terminal thiocarboxylate [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

0 Parent Features

7 Publications

First Author Title Year Journal Volume Pages
Hofmann K The PCI domain: a common theme in three multiprotein complexes. 1998 Trends Biochem Sci 23 204-5
Ponting CP Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. 1999 J Mol Biol 289 729-45
Iyer LM The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains. 2006 Genome Biol 7 R60
Kouranti I A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. 2010 PLoS Biol 8  
Verma R Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. 2002 Science 298 611-5
Hepowit NL Archaeal JAB1/MPN/MOV34 metalloenzyme (HvJAMM1) cleaves ubiquitin-like small archaeal modifier proteins (SAMPs) from protein-conjugates. 2012 Mol Microbiol 86 971-87
Godert AM Biosynthesis of the thioquinolobactin siderophore: an interesting variation on sulfur transfer. 2007 J Bacteriol 189 2941-4

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)