InterPro : IPR009078

Name  Ferritin-like superfamily Short Name  Ferritin-like_SF
Type  Domain Description  Ferritin is one of the major non-haem iron storage proteins in animals, plants, and microorganisms. It is a multisubunit protein with a hollow interior, which contains a mineral core of hydrated ferric oxide, thereby ensuring its solubility in an aqueous environment []. Each subunit consists of a closed, four-helical bundle with a left-handed twist and one crossover connection.This entry represents the ferritin-like superfamily. Proteins with this structure include ferritin and other ferritin-like proteins such as bacterioferritin (cytochrome b1) that binds haem between two subunits, non-haem ferritin, dodecameric ferritin homologue (DPS) that binds to and protects DNA, and the N-terminal domain of rubrerythrin that is found in many air-sensitive bacteria and archaea []. In addition, ribonucleotide reductase-like proteins show a similar structure to the ferritin-like fold; these di-iron carboxylate proteins constitute a diverse class of non-haem iron enzymes performing a multitude of redox reactions []. The superfamily also includes the alpha and beta subunits of methane monooxygenase hydrolase, delta 9-stearoyl-acyl carrier protein desaturase and manganese catalase.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

2 Child Features

Id Name Short Name Type
IPR012347 Ferritin-related Ferritin-rel Domain
IPR012348 Ribonucleotide reductase-related RNR-rel Domain

4 Contains

Id Name Short Name Type
IPR011017 TRASH domain TRASH_dom Domain
IPR014034 Ferritin, conserved site Ferritin_CS Conserved_site
IPR007029 YHS domain YHS_dom Domain
IPR005803 Stearoyl-ACP desaturase, conserved site Stearoyl-ACP_desaturase_CS Conserved_site

6 Found In

Id Name Short Name Type
IPR011566 Ubiquinone biosynthesis protein Coq7 Ubq_synth_Coq7 Family
IPR011971 Conserved hypothetical protein CHP02284 CHP02284 Family
IPR010386 tRNA-hydroxylase MiaE tRNA-Hydrxlase_MiaE Family
IPR017022 Uncharacterised conserved protein UCP033860 UCP033860 Family
IPR008434 Magnesium-protoporphyrin IX monomethyl ester aerobic oxidative cyclase AcsF Family
IPR017635 Benzoyl-CoA oxygenase, B subunit Benzoyl_CoA_Oase_BoxB_bsu Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Takagi H Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release? 1998 J Biol Chem 273 18685-8
Jin S X-ray crystal structures of reduced rubrerythrin and its azide adduct: a structure-based mechanism for a non-heme diiron peroxidase. 2002 J Am Chem Soc 124 9845-55
Högbom M Crystal structures of oxidized dinuclear manganese centres in Mn-substituted class I ribonucleotide reductase from Escherichia coli: carboxylate shifts with implications for O2 activation and radical generation. 2001 J Biol Inorg Chem 6 315-23



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)