InterPro : IPR000855

Name  Peptidase C5, adenain Short Name  Peptidase_C5
Type  Family Description  Cysteine peptidases have characteristic molecular topologies, which can be seen not only in their three-dimensional structures, but commonly also in the two-dimensional structures. These are peptidases in which the nucleophile is the sulphydryl group of a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related), and further sub-divided into families, on the basis of the architecture of their catalytic dyad or triad []. This group of cysteine aminopeptidases belong to the peptidase family C5 (adenain family, clan CE). Several adenovirus proteins are synthesised as precursors, requiringprocessing by a protease before the virion is assembled [, ]. Untilrecently, the adenovirus endopeptidase was classified as a serine protease,having been reported to be inhibited by serine protease inhibitors [, ].However, it has since been shown to be inhibited by cysteine proteaseinhibitors, and the catalytic residues are believed to be His-54 andCys-104 [, ].
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InterPro protein domain ID --> Contigs

 

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4 Publications

First Author Title Year Journal Volume Pages
Barrett AJ Evolutionary lines of cysteine peptidases. 2001 Biol Chem 382 727-33
Rawlings ND Families of cysteine peptidases. 1994 Methods Enzymol 244 461-86
Kräusslich HG Viral proteinases. 1988 Annu Rev Biochem 57 701-54
Bhatti AR Protease of adenovirus type 2: partial characterization. 1979 Virology 96 478-85



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)