InterPro : IPR006050

Name  DNA photolyase, N-terminal Short Name  DNA_photolyase_N
Type  Domain Description  The photolyase/cryptochrome family consists of flavoproteins that performvarious functions using blue-light photons as an energie source. It is presentin all three domains of life, that is, archaea, eubacteria, and eukaryotes,and hence has arisen very early during evolution to protect genomes againstthe genotoxic effects of ultraviolet light originating from the sun. Thephotolyase/cryptochrome family is divided into two major groups: photolyasesand cryptochromes. Photolyases repaircytotoxic and mutagenic UV-induced photolesions in DNA in many species frombacteria to plants and animals by using a light-dependent repair mechanism. Itinvolves light absorption, electron transfer from an excited reduced anddeprotanated FADH(-) to the flipped-out photolesion, followed by thefragmentation of the photolesions. Cryptochromes are highly related proteinsthat generally no longer repair damaged DNA, but function as photoreceptors.Cryptochromes regulate growth and development in plants and the circadianclock in animals [, , , , , , ].Both photolyases and cryptochromes have a bilobal architecture consisting oftwo domains: an N-terminal alpha/beta domain that may contain a light-harvesting chromophore to additionally broaden their activity spectra and a C-terminal alpha-helical catalytic domain comprising the light-sensitive FADcofactor. Diverse classes of antenna chromophores likes 5,10-methenyltetrahydrofolate (MTHF), 8-hydroxydeazaflavin, FMN or FAD have beenidentified in some photolyase/cryptochrome to broaden their activity spectra,whereas many others apparently lack any bound antenna chromophores.This entry represents the photolyase/cryptochrome alpha/beta domain. It adopts a dinucleotide binding fold with a five-stranded parallel beta sheet flanked on both sides by alpha helices [, ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold Rossmann-like_a/b/a_fold Domain

5 Found In

Id Name Short Name Type
IPR008148 DNA photolyase, class 2 DNA_photolyase_2 Family
IPR014133 Cryptochrome, DASH Cryptochrome_DASH Family
IPR002081 Cryptochrome/DNA photolyase, class 1 Cryptochrome/DNA_photolyase_1 Family
IPR014134 Cryptochrome, plant Cryptochrome_pln Family
IPR019947 Deoxyribodipyrimidine photo-lyase, 8-HDF type Photolyase_8HDF Family

0 Parent Features

7 Publications

First Author Title Year Journal Volume Pages
Brudler R Identification of a new cryptochrome class. Structure, function, and evolution. 2003 Mol Cell 11 59-67
Pokorny R Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome. 2008 Proc Natl Acad Sci U S A 105 21023-7
Glas AF The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes. 2009 Proc Natl Acad Sci U S A 106 11540-5
Hitomi K Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants. 2012 J Biol Chem 287 12060-9
Gerdes MJ Localization of transforming growth factor-beta1 and type II receptor in developing normal human prostate and carcinoma tissues. 1998 J Histochem Cytochem 46 379-88
Kiontke S Crystal structures of an archaeal class II DNA photolyase and its complex with UV-damaged duplex DNA. 2011 EMBO J 30 4437-49
Asimgil H Purification and characterization of five members of photolyase/cryptochrome family from Cyanidioschyzon merolae. 2012 Plant Sci 185-186 190-8

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)