InterPro : IPR006175

Name  YjgF/Yer057p/UK114 family Short Name  YjgF/Yer057p/UK114
Type  Family Description  The YjgF/Yer057p/UK114 family is a large, highly conserved, and widely distributed family of proteins found in bacteria, archaea and eukaryotes. YjgF (renamed RidA) deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions. The YjgF/YER057c/UK114 family of proteins is conserved in all domains of life suggesting that reactive enamine/imine metabolites are of concern to all organisms []. This family includes: YjgF and its orthologuesthe yeast growth inhibitor YER057cp that appears to play a role in the regulation of metabolic pathways and cell differentiation []the mammalian 14.5 kDa translational inhibitor protein UK114, also known as L-PSP (liver perchloric acid-soluble protein), with endoribonucleolytic activity that directly affects mRNA translation and can induce disaggregation of the reticulocyte polysomes into 80 S ribosomes []RutC from E. coli, which is essential for growth on uracil as sole nitrogen source and is thought to reduce aminoacrylate peracid to aminoacrylate []YabJ from B. subtilis, which is required for adenine-mediated repression of purine biosynthetic genes []Structurally these proteins are homotrimers with clefts between the monomeric subunits that are proposed to have some functional relevance [, , ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR006056 Enamine/imine deaminase YjgF-like YjgF-like Family
IPR019898 Putative aminoacrylate peracid reductase RutC RutC Family

1 Contains

Id Name Short Name Type
IPR019897 YjgF-like protein, conserved site YjgF-like_CS Conserved_site

0 Found In

0 Parent Features

8 Publications

First Author Title Year Journal Volume Pages
Lambrecht JA Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions. 2012 J Biol Chem 287 3454-61
Sinha S Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family. 1999 Proc Natl Acad Sci U S A 96 13074-9
Morishita R Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis. 1999 J Biol Chem 274 20688-92
Volz K A test case for structure-based functional assignment: the 1.2 A crystal structure of the yjgF gene product from Escherichia coli. 1999 Protein Sci 8 2428-37
Kim JM A member of the YER057c/yjgf/Uk114 family links isoleucine biosynthesis and intact mitochondria maintenance in Saccharomyces cerevisiae. 2001 Genes Cells 6 507-17
Deaconescu AM X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1). 2002 Proteins 48 431-6
Thakur KG Mycobacterium tuberculosis Rv2704 is a member of the YjgF/YER057c/UK114 family. 2010 Proteins 78 773-8
Kim KS The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. 2010 J Bacteriol 192 4089-102

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)