InterPro : IPR000859

Name  CUB domain Short Name  CUB_dom
Type  Domain Description  The CUB domain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins, many of which are developmentally regulated [, ]. These proteins are involved in a diverse range of functions, including complement activation, developmental patterning, tissue repair, axon guidance and angiogenesis, cell signalling, fertilisation, haemostasis, inflammation, neurotransmission, receptor-mediated endocytosis, and tumour suppression []. Many CUB-containing proteins are peptidases belonging to MEROPS peptidase families M12A (astacin) and S1A (chymotrypsin). Proteins containing a CUB domain include:Mammalian complement subcomponents C1s/C1r, which form the calcium-dependent complex C1, the first component of the classical pathway of the complement system.Cricetidae sp.(Hamster) serine protease Casp, which degrades type I and IV collagen and fibronectin in the presence of calcium.Mammalian complement-activating component of Ra-reactive factor (RARF), a protease that cleaves the C4 component of complement.Vertebrate enteropeptidase (), a type II membrane protein of the intestinal brush border, which activates trypsinogen.Vertebrate bone morphogenic protein 1 (BMP-1), a protein which induces cartilage and bone formation and expresses metalloendopeptidase activity.Sea urchin blastula proteins BP10 and SpAN.Caenorhabditis eleganshypothetical proteins F42A10.8 and R151.5.Neuropilin (A5 antigen), a calcium-independent cell adhesion molecule that functions during the formation of certain neuronal circuits.Fibropellins I and III from Strongylocentrotus purpuratus(Purple sea urchin).Mammalian hyaluronate-binding protein TSG-6 (or PS4), a serum and growth factor induced protein.Mammalian spermadhesins.Xenopus laevisembryonic protein UVS.2, which is expressed during dorsoanterior development.Several of the above proteins consist of a catalytic domain together with several CUB domains interspersed by calcium-binding EGF domains. Some CUB domains appear to be involved in oligomerisation and/or recognition of substrates and binding partners. For example, in the complement proteases, the CUB domains mediate dimerisation and binding to collagen-like regions of target proteins (e.g. C1q for C1r/C1s). The structure of CUB domains consists of a beta-sandwich with a jelly-roll fold. Almost all CUB domains contain four conserved cysteines that probably form two disulphide bridges (C1-C2, C3-C4). The CUB1 domains of C1s and Map19 have calcium-binding sites [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

11 Found In

Id Name Short Name Type
IPR011163 Peptidase S1A, enteropeptidase Pept_S1A_enterop Family
IPR017051 Peptidase S1A, matripase Peptidase_S1A_matripase Family
IPR017118 Peptidase S1A, matriptase-2 Pept_S1A_matriptase-2 Family
IPR016857 Uncharacterised conserved protein UCP027682, CUB, vWA UCP027682_CUB_vWA Family
IPR000124 Spermadhesin Spermadhesin Family
IPR015446 Bone morphogenetic protein 1/tolloid-like protein BMP_1/tolloid-like Family
IPR014648 Neuropilin Neuropilin Family
IPR017076 Kremen Kremen Family
IPR017369 SPAN protein/blastula protease 10 SPAN/blastula_protease_10 Family
IPR017050 Metallopeptidase, nematode Metallopeptidase_nem Family
IPR017370 Hatching enzyme, Uvs2 Hatching_enzyme_Uvs2 Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Bork P The CUB domain. A widespread module in developmentally regulated proteins. 1993 J Mol Biol 231 539-45
Bork P Complement components C1r/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeats. 1991 FEBS Lett 282 9-12
Blanc G Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity. 2007 J Biol Chem 282 16924-33
Perry SE Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. 2007 FEBS Lett 581 1137-42

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)