InterPro : IPR004088

Name  K Homology domain, type 1 Short Name  KH_dom_type_1
Type  Domain Description  The K homology (KH) domain was first identified in the human heterogeneousnuclear ribonucleoprotein (hnRNP) K. It is a domain of around 70 amino acidsthat is present in a wide variety of quite diverse nucleic acid-bindingproteins []. It has been shown to bind RNA [, ]. Like many other RNA-binding motifs, KH motifs are found in one or multiple copies (14 copies in chicken vigilin) and, at least for hnRNP K (three copies) and FMR-1 (two copies), each motif is necessary for in vitroRNA binding activity, suggesting that they may function cooperatively or, in the case of single KH motif proteins (for example, Mer1p), independently [].According to structural [, , ]analysis the KH domain can be separated in two groups. Thefirst group or type-1 contain a beta-alpha-alpha-beta-beta-alpha structure, whereas in the type-2 the two last beta-sheet are located in the N-terminal part of the domain (alpha-beta-beta-alpha-alpha-beta). Sequence similarity between these two folds are limited to a short region (VIGXXGXXI) in the RNA binding motif. This motif is located between helice 1 and 2 in type-1 and between helice 2 and 3 in type-2. Proteins known to contain a type-1 KH domain include bacterial polyribonucleotide nucleotidyltransferases (); vertebrate fragile X mental retardation protein 1 (FMR1); eukaryotic heterogeneous nuclear ribonucleoprotein K (hnRNP K), one of at least 20 major proteins that are part of hnRNP particles in mammalian cells; mammalian poly(rC) binding proteins; Artemia salinaglycine-rich protein GRP33; yeast PAB1-binding protein 2 (PBP2); vertebrate vigilin; and human high-density lipoprotein binding protein (HDL-binding protein).

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

8 Found In

Id Name Short Name Type
IPR012162 Polyribonucleotide nucleotidyltransferase PNPase Family
IPR010213 Transcription termination factor NusA Tscrpt_termination_fac_NusA Domain
IPR017705 Ribonuclease Y Ribonuclease_Y Family
IPR019964 KH domain protein, archaea KH_domain_protein_archaea Family
IPR020627 Uncharacterised protein family UPF0109 UPF0109 Family
IPR014069 Guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase pppGpp_PNP Family
IPR010212 NusA protein, KH domain-containing, archaeal NusA_KH-contain_arc Family
IPR009210 Activating signal cointegrator 1 complex subunit 1 ASCC1 Family

1 Parent Features

Id Name Short Name Type
IPR004087 K Homology domain KH_dom Domain

4 Publications

First Author Title Year Journal Volume Pages
Burd CG Conserved structures and diversity of functions of RNA-binding proteins. 1994 Science 265 615-21
Musco G The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome. 1997 Nat Struct Biol 4 712-6
Baber JL High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcription factor. 1999 J Mol Biol 289 949-62
Grishin NV KH domain: one motif, two folds. 2001 Nucleic Acids Res 29 638-43

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)