InterPro : IPR001132

Name  SMAD domain, Dwarfin-type Short Name  SMAD_dom_Dwarfin-type
Type  Domain Description  Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth []. The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Dpp []. This domain is also found in nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF).This entry represents the SMAD (Mothers against decapentaplegic (MAD) homologue) (also called MH2 for MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C terminus of MH2 [, , ].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR013790 Dwarfin Dwarfin Family

1 Parent Features

Id Name Short Name Type
IPR017855 SMAD domain-like SMAD_dom-like Domain

3 Publications

First Author Title Year Journal Volume Pages
Kim J Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. 1997 Nature 388 304-8
Yingling JM Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. 1996 Proc Natl Acad Sci U S A 93 8940-4
Attisano L The Smads. 2001 Genome Biol 2 REVIEWS3010



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)