InterPro : IPR000418

Name  Ets domain Short Name  Ets_dom
Type  Domain Description  Transcription factors are protein molecules that bind to specific DNAsequences in the genome, resulting in the induction or inhibition of genetranscription []. The ets oncogene is such a factor, possessing a region of 85-90 amino acids known as the ETS (erythroblast transformation specific) domain [, , ]. This domain is rich inpositively-charged and aromatic residues, and binds to purine-rich segmentsof DNA. The ETS domain has been identified in other transcription factorssuch as PU.1, human erg, human elf-1, human elk-1, GA binding protein, anda number of others [, , ].It is generally localized at the C terminus of the protein,with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found atthe N terminus.NMR-analysis of the structure of the Ets domains revealed that it contains three alpha-helixes (1-3)and four-stranded beta-sheets (1-4) arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4 forming awinged helix-turn-helix (wHTH) topology []. The third alpha-helix isresponsive to contact to the major groove of the DNA. Different members of the Ets family proteinsdisplay distinct DNA binding specificities. The Ets domains and the flanking amino acid sequencesof the proteins influence the binding affinity, and the alteration of asingle amino acid in the Ets domain can change its DNA binding specificities.
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

2 Found In

Id Name Short Name Type
IPR016311 Transforming protein C-ets Transform_prot_C-ets Family
IPR016312 Transcription factor, GA-binding, alpha subunit TF_GA-bd_asu Family

1 Parent Features

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

5 Publications

First Author Title Year Journal Volume Pages
Wasylyk B The Ets family of transcription factors. 1993 Eur J Biochem 211 7-18
Karim FD The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. 1990 Genes Dev 4 1451-3
Gunther CV Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus. 1990 Genes Dev 4 667-79
Oikawa T Molecular biology of the Ets family of transcription factors. 2003 Gene 303 11-34
Buchwalter G Ets ternary complex transcription factors. 2004 Gene 324 1-14



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)