InterPro : IPR007889

Name  DNA binding HTH domain, Psq-type Short Name  HTH_Psq
Type  Domain Description  The psq-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain ofabout 50 amino acids present in eukaryotic proteins of the Pipsqueak family.This family is named after the Drosophila pipsqueak protein, containing aDNA-binding domain that consists of four tandem repeats of the psq motif [].Proteins of the Pipsqueak family occur in vertebrates, insects, nematodes, andfungi. Three subgroups of the family have been described: BTB, E93 and CENP-B.Pipsqueak and the other proteins of the BTB group (Broad-Complex, Tramtrack,Bric a brac) contain a BTB protein-protein interaction domain in the N-terminal part, and the psq-type HTH domain(s) occur in the C-terminal part. Many BTB proteins are transcriptional regulators and the psq-type HTH domain binds DNA. The Drosophila cell death regulating protein E93 and human orthologs form the second subgroup and can contain the psq-type HTH at varying positions. The human centromere protein B (CENP-B) and the other members of the CENP-B group contain a psq-type DNA-binding domain in the N-terminal part and often a dimerisation domain in the C-terminal part. The CENP-B group includes fungal transposases that, however, lack the N-terminal extremity of the psq-type HTHdomain [].The structure of human CENP-B shows that the N-terminal part of the DNA binding domain is composed of three alpha-helices. The second and third helices connected via a turn comprise the helix-turn-helix motif. Helix 3 is termed the recognition helix as it binds the DNA major groove, like in other HTHs [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR009057 Homeodomain-like Homeodomain-like Domain

3 Publications

First Author Title Year Journal Volume Pages
Tanaka Y Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA. 2001 EMBO J 20 6612-8
Lehmann M The pipsqueak protein of Drosophila melanogaster binds to GAGA sequences through a novel DNA-binding domain. 1998 J Biol Chem 273 28504-9
Siegmund T The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins. 2002 Dev Genes Evol 212 152-7

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)