InterPro : IPR024909

Name  Cysteinyl-tRNA synthetase/mycothiol ligase Short Name  Cys-tRNA/MSH_ligase
Type  Family Description  This entry represents a subgroup of the class-I aminoacyl-tRNA synthetase family. It includes cysteinyl-tRNA synthetase and the related enzyme mycothiol ligase [].Cysteine-tRNA ligase (also known as Cysteinyl-tRNA synthetase) () is an alpha monomer and belongs to class Ia []. It is highly specific despite not possessing the amino acid editing activity characteristic of many other tRNA ligases [].Mycothiol ligase, also known as L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR015803 Cysteine-tRNA ligase Cys-tRNA-ligase Family
IPR017812 Mycothiol ligase MshC Mycothiol_ligase_MshC Family

0 Contains

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Newberry KJ Structural origins of amino acid selection without editing by cysteinyl-tRNA synthetase. 2002 EMBO J 21 2778-87
Hou YM Sequence determination and modeling of structural motifs for the smallest monomeric aminoacyl-tRNA synthetase. 1991 Proc Natl Acad Sci U S A 88 976-80
Newton GL A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening. 2006 Anal Biochem 353 167-73
Sareen D ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. 2002 Biochemistry 41 6885-90

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)