InterPro : IPR013032

Name  EGF-like, conserved site Short Name  EGF-like_CS
Type  Conserved_site Description  A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF)has been shown [, , , ]to be present, in a moreor less conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known tocontain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains inwhat appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found inthe extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandinG/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulphidebonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.Subdomains between the conserved cysteines vary in length.This entry represents a conserved site in the EGF-like domain.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

29 Found In

Id Name Short Name Type
IPR015455 Thrombospondin-2 Thrombospondin-2 Family
IPR001881 EGF-like calcium-binding domain EGF-like_Ca-bd_dom Domain
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain
IPR002049 EGF-like, laminin EGF_laminin Domain
IPR013111 EGF-like domain, extracellular EGF_extracell Domain
IPR015812 Integrin beta subunit Integrin_bsu Family
IPR011398 Fibrillin/Microneme protein4 FBN/EtMIC4 Family
IPR010423 Plasmodium ookinete surface Pvs28 Plasmod_Pvs28 Family
IPR015497 Epidermal growth factor receptor ligand EGF_rcpt_ligand Family
IPR015149 Thrombomodulin-like, EGF-like Tme5_EGF-like Domain
IPR002396 Selectin superfamily Selectin_superfamily Family
IPR016317 Pro-epidermal growth factor Pro-epidermal_GF Family
IPR016316 Complement component C1q/Thrombomodulin CD93/CD141 Family
IPR016348 L-selectin L-selectin Family
IPR008297 Notch Notch Family
IPR022355 Neurogenic locus Notch 4 Notch_4 Family
IPR018250 Neuregulin NRG1 Family
IPR012111 Hemolectin/hemocytin Hml Family
IPR012013 Integrin beta-4 subunit Integrin_bsu-4 Family
IPR015442 Integrin beta-8 subunit Integrin_bsu-8 Family
IPR014394 Coagulation factor XIIa/hepatocyte growth factor activator Coagulation_fac_XIIa/HGFA Family
IPR015446 Bone morphogenetic protein 1/tolloid-like protein BMP_1/tolloid-like Family
IPR017048 Fibulin-1 Fibulin-1 Family
IPR001491 Thrombomodulin Thrombomodulin Family
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z Pept_S1A_FX Family
IPR011170 Growth factor, vaccinia C11R type GF_C11R Family
IPR017047 Teratocarcinoma-derived growth factor Cripto Cripto_growth_factor Family
IPR017369 SPAN protein/blastula protease 10 SPAN/blastula_protease_10 Family
IPR017050 Metallopeptidase, nematode Metallopeptidase_nem Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Appella E Structure and function of epidermal growth factor-like regions in proteins. 1988 FEBS Lett 231 1-4
Doolittle RF Computer-based characterization of epidermal growth factor precursor. 1984 Nature 307 558-60
Davis CG The many faces of epidermal growth factor repeats. 1990 New Biol 2 410-9
Blomquist MC Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors. 1984 Proc Natl Acad Sci U S A 81 7363-7

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)