InterPro : IPR016040

Name  NAD(P)-binding domain Short Name  NAD(P)-bd_dom
Type  Domain Description  This entry represents NAD- and NADP-binding domains with a core Rossmann-type fold, which consists of 3-layers alpha/beta/alpha, where the six beta strands are parallel in the order 321456. Many different enzymes contain an NAD/NADP-binding domain, including:C-terminal domain of alcohol dehydrogenases []Tyrosine-dependent oxidoreductases (also known as short-chain dehydrogenases) []N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase []NAD-binding domain of formate/glycerate dehydrogenases []N-terminal domain of sirohaem synthase []N-terminal domain of lactate dehydrogenase []N-terminal domain of 6-phosphogluconate dehydrogenase (the beta-sheet is extended to 8 strands) []C-terminal domain of amino acid dehydrogenases (an extra N-terminal helix displaces the C-terminal helix []NAD-binding domain of certain potassium channels []C-terminal domain of the transcriptional repressor Rex []Ornithine cyclodeaminase []CoA-binding N-terminal domain of the alpha chain of succinyl-CoA synthetase []

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



23 Child Features

Id Name Short Name Type
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain D-isomer_DH_NAD-bd Domain
IPR001236 Lactate/malate dehydrogenase, N-terminal Lactate/malate_DH_N Domain
IPR006115 6-phosphogluconate dehydrogenase, NADP-binding 6PGDH_NADP-bd Domain
IPR008030 NmrA-like domain NmrA-like Domain
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal G3P_DH_NAD-dep_N Domain
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal ProC_N Domain
IPR013120 Male sterility, NAD-binding Male_sterile_NAD-bd Domain
IPR012302 Malic enzyme, NAD-binding Malic_NAD-bd Domain
IPR003781 CoA-binding CoA-bd Domain
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding 3-OHacyl-CoA_DH_NAD-bd Domain
IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal UDP-Glc/GDP-Man_DH_N Domain
IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding G6P_DH_NAD-bd Domain
IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal Glu/Leu/Phe/Val_DH_C Domain
IPR000846 Dihydrodipicolinate reductase, N-terminal DapB_N Domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DH/CycHdrlase_NAD-bd_dom Domain
IPR009036 Molybdenum cofactor biosynthesis, MoeB Molybdenum_cofac_synth_MoeB Domain
IPR013968 Polyketide synthase, ketoreductase domain PKS_KR Domain
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain Polysac_CapD-like Domain
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase 3Beta_OHSteriod_DH/Estase Domain
IPR013332 Ketopantoate reductase, N-terminal domain KPR_N Domain
IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase Shikm_DH/Glu-tRNA_Rdtase Domain
IPR006367 Sirohaem synthase, N-terminal Sirohaem_synthase_N Domain
IPR019665 Putative oxidoreductase/dehydrogenase, Rossmann-like domain OxRdtase/DH_put_Rossmann_dom Domain

18 Contains

Id Name Short Name Type
IPR000683 Oxidoreductase, N-terminal Oxidoreductase_N Domain
IPR019572 Ubiquitin-activating enzyme Ubiquitin-activating_enzyme Domain
IPR013549 Domain of unknown function DUF1731 DUF1731 Domain
IPR018074 Ubiquitin-activating enzyme, E1, active site UBQ-activ_enz_E1_AS Active_site
IPR020904 Short-chain dehydrogenase/reductase, conserved site Sc_DH/Rdtase_CS Conserved_site
IPR003148 Regulator of K+ conductance, N-terminal RCK_N Domain
IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site GlycerAld_3-P_DH_AS Active_site
IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site THF_DH/CycHdrlase_CS Conserved_site
IPR015884 Malic enzyme, conserved site Malic_enzyme_CS Conserved_site
IPR019796 Glucose-6-phosphate dehydrogenase, active site G6P_DH_AS Active_site
IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site S-Ado-L-homoCys_hydrolase_CS Conserved_site
IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site 3-OH-isobutyrate_DH-rel_CS Conserved_site
IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site Quin_OxRdtase/zeta-crystal_CS Conserved_site
IPR013131 Mannitol dehydrogenase, N-terminal Mannitol_DH_N Domain
IPR006181 D-amino acid oxidase, conserved site D-amino_acid_oxidase_CS Conserved_site
IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like Myo-inos-1-P_Synthase_GAPDH Domain
IPR006037 Regulator of K+ conductance, C-terminal RCK_C Domain
IPR008143 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 Ala_DH/PNT_CS2 Conserved_site

94 Found In

Id Name Short Name Type
IPR001557 L-lactate/malate dehydrogenase L-lactate/malate_DH Family
IPR002347 Glucose/ribitol dehydrogenase Glc/ribitol_DH Family
IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GlycerAld/Erythrose_P_DH Family
IPR000304 Pyrroline-5-carboxylate reductase Pyrroline-COOH_reductase Family
IPR003929 Potassium channel, calcium-activated, BK, alpha subunit K_chnl_Ca-activ_BK_asu Family
IPR010099 Epimerase family protein SDR39U1 SDR39U1 Family
IPR010945 Malate dehydrogenase, type 2 Malate_DH_type2 Family
IPR005097 Saccharopine dehydrogenase / Homospermidine synthase Saccharopine_DH/HSpermid_syn Family
IPR017476 UDP-glucose/GDP-mannose dehydrogenase UDP-Glc/GDP-Man Family
IPR005913 dTDP-4-dehydrorhamnose reductase family dTDP_dehydrorham_reduct Family
IPR001282 Glucose-6-phosphate dehydrogenase G6P_DH Family
IPR001891 Malic oxidoreductase Malic_OxRdtase Family
IPR002198 Short-chain dehydrogenase/reductase SDR DH_sc/Rdtase_SDR Family
IPR018075 Ubiquitin-activating enzyme, E1 UBQ-activ_enz_E1 Family
IPR008089 Nucleotide sugar epimerase Nuc_sugar_epim Family
IPR005886 UDP-glucose 4-epimerase GalE GalE Family
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase THF_DH/CycHdrlase Family
IPR010097 Malate dehydrogenase, type 1 Malate_DH_type1 Family
IPR011274 Malate dehydrogenase, NAD-dependent, cytosolic Malate_DH_NAD-dep_euk Family
IPR013952 Protein of unknown function DUF1776, fungi DUF1776_fun Family
IPR006368 GDP-mannose 4,6-dehydratase GDP_Man_deHydtase Family
IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I Glyceraldehyde-3-P_DH_1 Family
IPR000669 Mannitol dehydrogenase Mannitol_DH Family
IPR011304 L-lactate dehydrogenase L-lactate_DH Family
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase DHB_DH Family
IPR001088 Glycoside hydrolase, family 4 Glyco_hydro_4 Family
IPR006422 D-erythrose-4-phosphate dehydrogenase E4P_DH_bac Family
IPR002587 Myo-inositol-1-phosphate synthase Myo-inos-1-P_Synthase Family
IPR003462 Ornithine cyclodeaminase/mu-crystallin ODC_Mu_crystall Family
IPR005888 dTDP-glucose 4,6-dehydratase dTDP_Gluc_deHydtase Family

0 Parent Features

12 Publications

First Author Title Year Journal Volume Pages
Stroupe ME CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis. 2003 Nat Struct Biol 10 1064-73
Read JA Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. 2001 Proteins 43 175-85
Thoden JB Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. 1997 Biochemistry 36 6294-304
Jiang Y Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. 2001 Neuron 29 593-601
Fraser ME A detailed structural description of Escherichia coli succinyl-CoA synthetase. 1999 J Mol Biol 285 1633-53
Isupov MN Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. 1999 J Mol Biol 291 651-60
Yip KS The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures. 1995 Structure 3 1147-58
Gibbons BJ Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors. 2004 Biochemistry 43 12555-62
Goodman JL Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family. 2004 Biochemistry 43 13883-91
Sickmier EA X-ray structure of a Rex-family repressor/NADH complex insights into the mechanism of redox sensing. 2005 Structure 13 43-54
Lamzin VS High resolution structures of holo and apo formate dehydrogenase. 1994 J Mol Biol 236 759-85
Sundaramoorthy R Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. 2007 FEBS J 274 275-86

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)