InterPro : IPR002073

Name  3'5'-cyclic nucleotide phosphodiesterase, catalytic domain Short Name  PDEase_catalytic_dom
Type  Domain Description  The cyclic nucleotide phosphodiesterases (PDE) comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They are divided into 11 families. They regulate the localisation, duration and amplitude of cyclic nucleotide signalling within subcellular domains. PDEs are therefore important for signal transduction.PDE enzymes are often targets for pharmacological inhibition due to their unique tissue distribution, structural properties, and functional properties. Inhibitors include: Roflumilast for chronic obstructive pulmonary disease and asthma [], Sildenafil for erectile dysfunction []and Cilostazol for peripheral arterial occlusive disease [], amongst others.Retinal 3',5'-cGMP phosphodiesterase is located in photoreceptor outer segments: it is light activated, playing a pivotal role in signal transduction. In rod cells, PDE is oligomeric, comprising an alpha-, a beta- and 2 gamma-subunits, while in cones, PDE is a homodimer of alpha chains, which are associated with several smaller subunits. Both rod and cone PDEs catalyse the hydrolysis of cAMP or cGMP to the corresponding nucleoside 5' monophosphates, both enzymes also bindingcGMP with high affinity. The cGMP-binding sites are located in theN-terminal half of the protein sequence, while the catalytic core resides in the C-terminal portion.This entry represents the catalytic domain of PDE which is multihelical and can be divided into three subdomains.
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1 Parent Features

Id Name Short Name Type
IPR003607 HD/PDEase domain HD/PDEase_dom Domain

3 Publications

First Author Title Year Journal Volume Pages
Field SK Roflumilast: an oral, once-daily selective PDE-4 inhibitor for the management of COPD and asthma. 2008 Expert Opin Investig Drugs 17 811-8
Ghiadoni L Phosphodiesterase 5 inhibition in essential hypertension. 2008 Curr Hypertens Rep 10 52-7
Stone WM Type 3 phosphodiesterase inhibitors may be protective against cerebrovascular events in patients with claudication. 2008 J Stroke Cerebrovasc Dis 17 129-33



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)