InterPro : IPR015590

Name  Aldehyde dehydrogenase domain Short Name  Aldehyde_DH_dom
Type  Domain Description  Aldehyde dehydrogenases (and ) are enzymes that oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor. In mammals at least four different forms of the enzyme are known []: class-1 (or Ald C) a tetrameric cytosolicenzyme, class-2 (or Ald M) a tetrameric mitochondrial enzyme, class- 3 (or Ald D) a dimeric cytosolic enzyme, and class IV a microsomal enzyme. Aldehyde dehydrogenases have also been sequenced from fungal and bacterial species. A number of enzymes are known to be evolutionary related to aldehyde dehydrogenases. A glutamic acid and a cysteine residue have been implicated in the catalytic activity of mammalian aldehyde dehydrogenase. These residues are conserved in all the enzymes of this entry.Some of the proteins in this entry are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen, stings, drugs, or food) that, in most people, result in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature SubcommitteeKing T.P., Hoffmann D., Loewenstein H., Marsh D.G., Platts-Mills T.A.E.,Thomas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed ofthe first three letters of the genus; a space; the first letter of thespecies name; a space and an arabic number. In the event that two speciesnames have identical designations, they are discriminated from one anotherby adding one or more letters (as necessary) to each species designation.The allergens in this family include allergens with the following designations: Alt a 10 and Cla h 3.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR000965 Gamma-glutamyl phosphate reductase GPR G-glutamylP_reductase Domain

4 Contains

Id Name Short Name Type
IPR016163 Aldehyde dehydrogenase, C-terminal Ald_DH_C Domain
IPR016162 Aldehyde dehydrogenase N-terminal domain Ald_DH_N Domain
IPR020593 Gamma-glutamyl phosphate reductase GPR, conserved site G-glutamylP_reductase_CS Conserved_site
IPR016160 Aldehyde dehydrogenase, cysteine active site Ald_DH_CS_CYS Conserved_site

19 Found In

Id Name Short Name Type
IPR010061 Methylmalonate-semialdehyde dehydrogenase MeMal-semiAld_DH Family
IPR005931 Delta-1-pyrroline-5-carboxylate dehydrogenase P5CDH/ALDH4A1 Family
IPR011264 NAD/NADP-dependent betaine aldehyde dehydrogenase BADH Family
IPR017649 Succinylglutamic semialdehyde dehydrogenase SuccinylGlu_semiald_DH_AstD Family
IPR011407 10-formyltetrahydrofolate dehydrogenase 10_FTHF_DH Family
IPR011408 Aldehyde dehydrogenase Aldehyde_DH Family
IPR017749 1-pyrroline dehydrogenase 1-pyrroline_dehydrogenase Family
IPR012394 Aldehyde dehydrogenase NAD(P)-dependent Aldehyde_DH_NAD(P) Family
IPR011985 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase DH_HpaE Family
IPR017628 2-hydroxymuconic semialdehyde dehydrogenase OHmuconic_semiald_DH Family
IPR010102 Succinate semialdehyde dehydrogenase Succ_semiAld_DH Family
IPR017656 Putative phosphonoacetaldehyde dehydrogenase Put_phosphonoacetaldehyde_DH Family
IPR011966 Phenylacetic acid degradation protein PaaN PaaN-DH Family
IPR005932 Putative 1-pyrroline-5-carboxylate dehydrogenase, Bacillales RocA Family
IPR005933 Delta-1-pyrroline-5-carboxylate dehydrogenase 3 Delta1-pyrroline-5-COlate_DH-3 Domain
IPR012408 Acetaldehyde/propionaldehyde dehydrogenase, EutE/PduP-related Acetald_propionald_DH-rel Family
IPR012079 Bifunctional aldehyde-alcohol dehydrogenase Bifunc_Ald-ADH Family
IPR011975 Phenylacetic acid degradation protein PaaN2 PaaN_2 Family
IPR013357 Acetaldehyde dehydrogenase, acetylating Acetaldehyde_DH_acetylating Family

1 Parent Features

Id Name Short Name Type
IPR016161 Aldehyde/histidinol dehydrogenase Ald_DH/histidinol_DH Domain

1 Publications

First Author Title Year Journal Volume Pages
Hempel J Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria. 1989 Biochemistry 28 1160-7

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)