InterPro : IPR029060

Name  PIN domain-like Short Name  PIN_domain-like
Type  Domain Description  This entry represents a domain sharing protein structural similarity with the PIN domain. This domain can also be found in the N-terminal of the 5'3'-exonuclease, which has a 3-layer alpha/beta/alpha core structure and contains an alpha-helical arch [].PIN domains are small protein domains identified by the presence of three strictly conserved acidic residues. Apart from these three residues, there is poor sequence conservation []. PIN domains are found in eukaryotes, eubacteria and archaea. In eukaryotes they are ribonucleases involved in nonsense mediated mRNA decay []and in processing of 18S ribosomal RNA []. In prokaryotes, they are the toxic components of toxin-antitoxin (TA) systems, their toxicity arising by virtue of their ribonuclease activity. The PIN domain TA systems are now called VapBC TAs(virulence associated proteins), where VapB is the inhibitor and VapC, the PIN-domain ribonuclease toxin [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



3 Child Features

Id Name Short Name Type
IPR002716 PIN domain PIN_dom Domain
IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal 5-3_exonucl_a-hlix_arch_N Domain
IPR021139 NYN domain, limkain-b1-type NYN_limkain-b1 Domain

0 Contains

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Glavan F Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. 2006 EMBO J 25 5117-25
Arcus VL The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array. 2011 Protein Eng Des Sel 24 33-40
Lamanna AC Nob1 binds the single-stranded cleavage site D at the 3'-end of 18S rRNA with its PIN domain. 2009 Proc Natl Acad Sci U S A 106 14259-64
Ceska TA A helical arch allowing single-stranded DNA to thread through T5 5'-exonuclease. 1996 Nature 382 90-3

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)