InterPro : IPR019594

Name  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain Short Name  Glu/Gly-bd
Type  Domain Description  This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and binds L-glutamate and glycine in the ionotropic glutamate receptor NMDA [, ]. It is found in association with . Ionotropic Receptors (IRs) are a variant subfamily of the Ionotropic glutamate receptors (iGluRs). In IRs, the ligand binding domain lacks one or more residues that directly contact the glutamate ligand in iGluRs [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

2 Found In

Id Name Short Name Type
IPR001320 Ionotropic glutamate receptor Iontro_rcpt Domain
IPR001508 Ionotropic glutamate receptor, metazoa Iono_rcpt_met Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Croset V Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. 2010 PLoS Genet 6 e1001064
Ishii T Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. 1993 J Biol Chem 268 2836-43
Yamakura T Subunit- and site-specific pharmacology of the NMDA receptor channel. 1999 Prog Neurobiol 59 279-98

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)