InterPro : IPR001320

Name  Ionotropic glutamate receptor Short Name  Iontro_rcpt
Type  Domain Description  Ionotropic glutamate receptors (iGluRs) are a highly conserved family of ligand-gated ion channels present in animals, plants, and bacteria, which are best characterised for their roles in synaptic communication in vertebrate nervous systems []. A variant subfamily of iGluRs, the Ionotropic Receptors (IRs), consist of non-glutamate-binding chemosensory receptors first identified in Drosophila melanogaster. They function in detecting odors and tastants [].There are three classes of ionotropic glutamate receptors (iGluRs), namely NMDA (N-methyl-D-aspartate), AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid) and kainate receptors. They are believed to play critical roles in synaptic plasticity. At many synapses in the brain, transient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors and kainate receptors can act as the induction trigger for long-term changes in synaptic transmission [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain Glu/Gly-bd Domain

2 Found In

Id Name Short Name Type
IPR001508 Ionotropic glutamate receptor, metazoa Iono_rcpt_met Family
IPR017103 Ionotropic glutamate receptor, plant Iontropic_Glu_rcpt_pln Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Bortolotto ZA Kainate receptors are involved in synaptic plasticity. 1999 Nature 402 297-301
Mayer ML Structure and function of glutamate receptor ion channels. 2004 Annu Rev Physiol 66 161-81
Croset V Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. 2010 PLoS Genet 6 e1001064

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)