InterPro : IPR008979

Name  Galactose-binding domain-like Short Name  Galactose-bd-like
Type  Domain Description  Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [].The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



19 Child Features

Id Name Short Name Type
IPR000421 Coagulation factor 5/8 C-terminal type domain Coagulation_fac_5/8-C_type_dom Domain
IPR001090 Ephrin receptor ligand binding domain Ephrin_rcpt_lig-bd_dom Domain
IPR010400 PITH domain PITH_dom Domain
IPR002706 DNA-repair protein Xrcc1, N-terminal Xrcc1_N Domain
IPR006104 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2_N Domain
IPR015176 Lyase, N-terminal Lyase_N Domain
IPR010565 Muskelin, N-terminal Muskelin_N Domain
IPR025300 Beta-galactosidase jelly roll domain BetaGal_jelly_roll_dom Domain
IPR005084 Carbohydrate binding module family 6 CMB_fam6 Domain
IPR003305 Carbohydrate-binding, CenC-like CenC_carb-bd Domain
IPR015908 Allantoicase domain Allantoicase_dom Domain
IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal Xaa-Pro_dipept_C Domain
IPR005088 Carbohydrate binding module family 15 CBM_fam15 Domain
IPR005086 Carbohydrate binding module family 17/28 CBM_fam_17/28 Domain
IPR005087 Carbohydrate binding module family 11 CBM_fam11 Domain
IPR029411 Rhamnogalacturonan lyase, domain III RG-lyase_III Domain
IPR005638 Delta endotoxin, C-terminal Endotoxin_C Domain
IPR015295 Carbohydrate binding module 27 Carb-bd_module_27 Domain
IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module Glyco_hyd_98_carb-bd Domain

1 Contains

Id Name Short Name Type
IPR001426 Tyrosine-protein kinase, receptor class V, conserved site Tyr_kinase_rcpt_V_CS Conserved_site

13 Found In

Id Name Short Name Type
IPR001944 Glycoside hydrolase, family 35 Glycoside_Hdrlase_35 Family
IPR006585 Fucolectin tachylectin-4 pentraxin-1 FTP1 Domain
IPR016257 Ephrin receptor type-A /type-B Tyr_kinase_ephrin_rcpt Family
IPR016590 Rhamnogalacturonase B Rhamnogalacturonase_B Family
IPR016625 Uncharacterised conserved protein UCP014872, subtilisin-related UCP014872_subtilisin-rel Family
IPR016901 Anaphase-promoting complex, subunit 10 APC_su10 Family
IPR008252 Peptidase S15, X-Pro dipeptidyl-peptidase Pept_S15_Xpro Family
IPR017313 Peptidase S8A, subtilisin-related, clostridia-2 Pept_S8A_subtilisin_clostrid-2 Family
IPR017319 Peptidase S8A, subtilisin-related, prokarya Pept_S8A_subtilisin_pro Family
IPR017323 Lysyl endopeptidase Lysyl_endo-pept Family
IPR020766 Receptor-like tyrosine-protein kinase kin-15/kin-16 kin-15/kin-16 Family
IPR012905 PA-IL-like PA-IL Family
IPR010900 Nicotine adenine dinucleotide glycohydrolase NA_dinucl_GlycHdrlase Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Himanen JP Crystal structure of an Eph receptor-ephrin complex. 2001 Nature 414 933-8
Marintchev A Solution structure of the single-strand break repair protein XRCC1 N-terminal domain. 1999 Nat Struct Biol 6 884-93
Ito N Novel thioether bond revealed by a 1.7 A crystal structure of galactose oxidase. 1991 Nature 350 87-90
Macedo-Ribeiro S Crystal structures of the membrane-binding C2 domain of human coagulation factor V. 1999 Nature 402 434-9

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)