InterPro : IPR028996

Name  Ganglioside GM2 activator Short Name  GM2-AP
Type  Family Description  Ganglioside GM2 activator (GM2-AP) is a is a lysosomal lipid transfer protein that is essential for the hydrolytic conversion of ganglioside GM2 to GM3 by beta-hexosaminidase A []. The crystal structure of apo-GM2-AP consists of a novel beta-cup fold with a spacious hydrophobic interior [, ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Wright CS Structural analysis of lipid complexes of GM2-activator protein. 2003 J Mol Biol 331 951-64
Wright CS Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity. 2005 Biochemistry 44 13510-21

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)