InterPro : IPR000884

Name  Thrombospondin, type 1 repeat Short Name  Thrombospondin_1_rpt
Type  Repeat Description  Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. They act as regulators of cell interactions in vertebrates. They are divided into two subfamilies, A and B, according to their overall molecular organisation. The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. They are assembled as trimer. The subgroup B thrombospondins, designated TSP-3, -4, and COMP (cartilage oligomeric matrix protein, also designated TSP-5) are distinct in that they contain unique N-terminal regions, lack the VWFC domain and TSP1 repeats, contain four copies of EGF-like domains, and are assembled as pentamers []. EGF, TSP3 repeats and the C-terminal domain are thus the hallmark of a thrombospondin.This repeat was first described in 1986 by Lawler and Hynes []. It was found in the thrombospondin protein where it is repeated 3 times. Now a number of proteins involved in the complement pathway (properdin, C6, C7, C8A, C8B, C9) []as well as extracellular matrix protein like mindin, F-spondin [], SCO-spondin and even the circumsporozoite surface protein 2 and TRAP proteins of Plasmodium [, ]contain one or more instance of this repeat.It has been involved in cell-cell interaction, inhibition of angiogenesis []andapoptosis [].The intron-exon organisation of the properdin gene confirms the hypothesis that the repeat might have evolved by a process involving exon shuffling [].A study of properdin structure provides some information about the structure ofthe thrombospondin type I repeat [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

10 Found In

Id Name Short Name Type
IPR015455 Thrombospondin-2 Thrombospondin-2 Family
IPR013273 Peptidase M12B, ADAM-TS Peptidase_M12B_ADAM-TS Family
IPR013274 Peptidase M12B, ADAM-TS1 Pept_M12B_ADAM-TS1 Family
IPR012395 IGFBP-related, CNN IGFBP_CNN Family
IPR008077 GPCR, family 2, brain-specific angiogenesis inhibitor GPCR_2_brain-spec_angio_inhib Family
IPR013275 Peptidase M12B, ADAM-TS2 Pept_M12B_ADAM-TS2 Family
IPR013276 Peptidase M12B, ADAM-TS5 Pept_M12B_ADAM-TS5 Family
IPR001862 Membrane attack complex component/perforin/complement C9 MAC_perforin Family
IPR003067 Plasmodium circumsporozoite protein Crcmsprzoite Family
IPR013277 Peptidase M12B, ADAM-TS8 Pept_M12B_ADAM-TS8 Family

0 Parent Features

10 Publications

First Author Title Year Journal Volume Pages
Patthy L Detecting distant homologies of mosaic proteins. Analysis of the sequences of thrombomodulin, thrombospondin complement components C9, C8 alpha and C8 beta, vitronectin and plasma cell membrane glycoprotein PC-1. 1988 J Mol Biol 202 689-96
Lawler J The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. 1986 J Cell Biol 103 1635-48
Wengelnik K The A-domain and the thrombospondin-related motif of Plasmodium falciparum TRAP are implicated in the invasion process of mosquito salivary glands. 1999 EMBO J 18 5195-204
Rogers WO Characterization of the gene encoding sporozoite surface protein 2, a protective Plasmodium yoelii sporozoite antigen. 1992 Mol Biochem Parasitol 53 45-51
Nolan KF Characterization of the human properdin gene. 1992 Biochem J 287 ( Pt 1) 291-7
Smith KF Neutron and X-ray scattering studies on the human complement protein properdin provide an analysis of the thrombospondin repeat. 1991 Biochemistry 30 8000-8
Feinstein Y F-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons. 1999 Development 126 3637-48
Guo N Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells. 1997 Cancer Res 57 1735-42
Iruela-Arispe ML Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats. 1999 Circulation 100 1423-31
Adams JC Thrombospondins: multifunctional regulators of cell interactions. 2001 Annu Rev Cell Dev Biol 17 25-51

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)