InterPro : IPR006630

Name  RNA-binding protein Lupus La Short Name  Lupus_La_RNA-bd
Type  Domain Description  Human Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome []. In the nucleus, La acts as a RNA polymerase III (RNAP III) transcription factor, while in the cytoplasm, La acts as a translation factor []. In the nucleus, La binds to the 3'UTR of nascent RNAP III transcripts to assist in folding and maturation []. In the cytoplasm, La recognises specific classes of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis []. The specific recognition is mediated by the N-terminal domain of La, which comprises a La motif and a RNA recognition motif (RRM). The La motif adopts an alpha/beta fold that comprises a winged-helix motif [].Homologous La domain-containing proteins have been identified in a wide range of organisms except Archaea, bacteria and viruses [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

1 Found In

Id Name Short Name Type
IPR002344 Lupus La protein Lupus_La Family

1 Parent Features

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

6 Publications

First Author Title Year Journal Volume Pages
Izumi RE A peptide from autoantigen La blocks poliovirus and hepatitis C virus cap-independent translation and reveals a single tyrosine critical for La RNA binding and translation stimulation. 2004 J Virol 78 3763-76
Intine RV Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs. 2003 Mol Cell 12 1301-7
Keene JD Posttranscriptional generation of macromolecular complexes. 2003 Mol Cell 12 1347-9
Alfano C Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. 2004 Nat Struct Mol Biol 11 323-9
Lin-Marq N A yeast RNA binding protein that resembles the human autoantigen La. 1995 J Mol Biol 245 81-5
Kenan DJ La gets its wings. 2004 Nat Struct Mol Biol 11 303-5



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)