InterPro : IPR000276

Name  G protein-coupled receptor, rhodopsin-like Short Name  GPCR_Rhodpsn
Type  Family Description  G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [, , ].This entry represents the G protein-coupled receptor, rhodopsin-like family.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



75 Child Features

Id Name Short Name Type
IPR002131 Glycoprotein hormone receptor family Gphrmn_rcpt_fam Family
IPR008365 Prostanoid receptor Prostanoid_rcpt Family
IPR000611 Neuropeptide Y receptor family NPY_rcpt Family
IPR000405 Galanin receptor family Galanin_rcpt Family
IPR001760 Opsin Opsin Family
IPR000995 Muscarinic acetylcholine receptor family Musac_Ach_rcpt Family
IPR001681 Neurokinin receptor Neurokn_rcpt Family
IPR002120 Thyrotropin-releasing hormone receptor TRH_rcpt_1 Family
IPR001556 Bombesin receptor Bombsn_rcpt Family
IPR000929 Dopamine receptor family Dopamine_rcpt Family
IPR002232 5-Hydroxytryptamine 6 receptor 5HT6_rcpt Family
IPR005390 Neuromedin U receptor NeuromedU_rcpt Family
IPR002231 5-hydroxytryptamine receptor family 5HT_rcpt Family
IPR001817 Vasopressin receptor Vasoprsn_rcpt Family
IPR002002 Octopamine receptor Octopmn_rcpt Family
IPR002233 Adrenoceptor family ADR_fam Family
IPR001671 Melanocortin/ACTH receptor Melcrt_ACTH_rcpt Family
IPR001402 Prolactin-releasing peptide receptor Prolrel_pep_rcpt Family
IPR000355 Chemokine receptor family Chemokine_rcpt Family
IPR000204 Orexin receptor family Orexin_rcpt Family
IPR002962 Peropsin Peropsin Family
IPR005395 Neuropeptide FF receptor family NPFF_rcpt Family
IPR003980 Histamine H3 receptor Histamine_H3_rcpt Family
IPR004065 Lysophosphatidic acid receptor LPA_rcpt Family
IPR004061 Sphingosine 1-phosphate receptor S1P_rcpt Family
IPR004071 Cysteinyl leukotriene receptor Cyst_leuk_rcpt Family
IPR008361 Melanin-concentrating hormone receptor MCH_rcpt Family
IPR028016 Hydroxycarboxylic acid receptor 1 HCAR1_rcpt Family
IPR028017 Hydroxycarboxylic acid receptor 2/3 HCAR2/3_rcpt Family
IPR028334 G protein-coupled receptor 55 orphan GPR55 Family

0 Contains

0 Found In

0 Parent Features

10 Publications

First Author Title Year Journal Volume Pages
Birnbaumer L G proteins in signal transduction. 1990 Annu Rev Pharmacol Toxicol 30 675-705
Casey PJ G protein involvement in receptor-effector coupling. 1988 J Biol Chem 263 2577-80
Attwood TK Design of a discriminating fingerprint for G-protein-coupled receptors. 1993 Protein Eng 6 167-76
Attwood TK Fingerprinting G-protein-coupled receptors. 1994 Protein Eng 7 195-203
Vassilatis DK The G protein-coupled receptor repertoires of human and mouse. 2003 Proc Natl Acad Sci U S A 100 4903-8
Kolakowski LF Jr GCRDb: a G-protein-coupled receptor database. 1994 Receptors Channels 2 1-7
Foord SM International Union of Pharmacology. XLVI. G protein-coupled receptor list. 2005 Pharmacol Rev 57 279-88
Harmar AJ IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. 2009 Nucleic Acids Res 37 D680-5
Bjarnadóttir TK Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. 2006 Genomics 88 263-73
Civelli O G protein-coupled receptor deorphanizations. 2013 Annu Rev Pharmacol Toxicol 53 127-46

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)