InterPro : IPR014044

Name  CAP domain Short Name  CAP_domain
Type  Domain Description  The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) superfamily proteins are found in a wide range of organisms, including prokaryotes []and non-vertebrate eukaryotes [], The nine subfamilies of the mammalian CAP superfamily include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP superfamily results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences []. The Ca++-chelating function []would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how blocks the Ca++ transporting ryanodine receptors. This entry represents the CAP domain common to all members of the CAP superfamily. The CAP domain forms a unique 3 layer alpha-beta-alpha fold with some, though not all, of the structural elements found in proteases [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

1 Child Features

Id Name Short Name Type
IPR014258 CAP domain, YkwD-like CAP_domain_YkwD-like Domain

1 Contains

Id Name Short Name Type
IPR018244 Allergen V5/Tpx-1-related, conserved site Allrgn_V5/Tpx1_CS Conserved_site

2 Found In

Id Name Short Name Type
IPR001283 Cysteine-rich secretory protein, allergen V5/Tpx-1-related Allrgn_V5/Tpx1 Family
IPR002413 Ves allergen V5_allergen Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Yeats C New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor. 2003 BMC Microbiol 3 3
Milne TJ Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. 2003 J Biol Chem 278 31105-10
Gibbs GM The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense. 2008 Endocr Rev 29 865-97



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)