InterPro : IPR008974

Name  TRAF-like Short Name  TRAF-like
Type  Domain Description  The tumour necrosis factor receptor (TNFR) associated factors (TRAFs) act as signal transducers for both TNFRs and interleukin-1/Toll-like receptors. TRAFs function in immunity, embryonic development, stress response and bone metabolism through their induction of cell proliferation, differentiation, and apoptosis []. TRAFs are characterised by two domains: an N-terminal domain containing RING and zinc finger motifs that is essential for the activation of downstream effectors, and a C-terminal TRAF domain that is essential for self-association and receptor interaction []. The TRAF-domain like fold is a beta-sandwich consisting of 8 strands in 2 beta sheets and has a circularly permuted greek-key immunoglobulin-fold topology that contains an extra strand.The substrate-binding domain (SBD) of the SIAH (seven in absentia homolog) family of proteins is structurally highly similar to the TRAF domain. The SIAH SBD interacts with a number of proteins, and is involved in TNF-alpha-mediated NFkappaB activation [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR002083 MATH MATH Domain
IPR018121 Seven-in-absentia protein, TRAF-like domain 7-in-absentia-prot_TRAF-dom Domain

3 Contains

Id Name Short Name Type
IPR001293 Zinc finger, TRAF-type Znf_TRAF Domain
IPR013323 SIAH-type domain SIAH-type Domain
IPR013010 Zinc finger, SIAH-type Znf_SIAH Domain

1 Found In

Id Name Short Name Type
IPR004162 E3 ubiquitin-protein ligase SINA like SINA_like Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Ye H The structural basis for the recognition of diverse receptor sequences by TRAF2. 1999 Mol Cell 4 321-30
Chung JY All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. 2002 J Cell Sci 115 679-88
Polekhina G Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. 2002 Nat Struct Biol 9 68-75

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)