InterPro : IPR011009

Name  Protein kinase-like domain Short Name  Kinase-like_dom
Type  Domain Description  Protein kinases () modify other proteins by chemically adding phosphate groups to them. This process is fundamental to most signalling and regulatory processes in the eukaryotic cell []. The protein kinases contain a catalytic core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold, which is found in enzymes that catalyse the formation of an amide bond. The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include:the catalytic domain of phosphoinositide-3-kinase (PI3K), which phosphorylates phosphoinositides and, as such, is involved in a number of fundamental cellular processes such as apoptosis, proliferation, motility and adhesion []choline kinase, which catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine []3',5'-aminoglycoside phosphotransferase type IIIa, a bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics []This entry represents the protein-kinase domain and other related domains that share a similar structure.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



7 Child Features

Id Name Short Name Type
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain PI3/4_kinase_cat_dom Domain
IPR004147 UbiB domain UbiB_dom Domain
IPR004166 MHCK/EF2 kinase MHCK_EF2_kinase Domain
IPR002575 Aminoglycoside phosphotransferase Aminoglycoside_PTrfase Domain
IPR015275 Actin-fragmin kinase, catalytic domain Actin-fragmin_kin_cat_dom Domain
IPR015897 CHK kinase-like CHK_kinase-like Domain

10 Contains

Id Name Short Name Type
IPR003605 TGF beta receptor, GS motif TGF_beta_rcpt_GS Domain
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR008266 Tyrosine-protein kinase, active site Tyr_kinase_AS Active_site
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site PI3/4_kinase_CS Conserved_site
IPR003527 Mitogen-activated protein (MAP) kinase, conserved site MAP_kinase_CS Conserved_site
IPR018935 RIO kinase, conserved site RIO_kinase_CS Conserved_site
IPR002011 Tyrosine-protein kinase, receptor class II, conserved site Tyr_kinase_rcpt_2_CS Conserved_site
IPR001824 Tyrosine-protein kinase, receptor class III, conserved site Tyr_kinase_rcpt_3_CS Conserved_site
IPR007521 Choline kinase, N-terminal Choline_kin_N Domain

61 Found In

Id Name Short Name Type
IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase Ca/CaM-dep_Ca-dep_prot_Kinase Family
IPR015433 Phosphatidylinositol Kinase PI_Kinase Family
IPR015725 Telokin/Myosin light chain kinase Telokin/Myosin_light_ch_kin Family
IPR017407 Serine/threonine-protein kinase Rio1 Ser/Thr_kinase_Rio1 Family
IPR002291 Phosphorylase kinase, gamma catalytic subunit Phosph_kin_gamma Family
IPR000239 GPCR kinase GPCR_kinase Family
IPR002374 cGMP-dependent kinase cGMP_dep_kinase Family
IPR020675 Myosin light chain kinase-related Myosin_light_ch_kinase-rel Family
IPR010232 Probable protein kinase UbiB UbiB Family
IPR008350 Mitogen-activated protein (MAP) kinase, ERK3/4 MAPK_ERK3/4 Family
IPR015782 Dual specificity testis-specific protein kinase 1 TESK1 Family
IPR020676 Death-associated protein kinase 1 DAPK1 Family
IPR017184 Serine/threonine-protein kinase Unc-51 Ser/Thr_kinase_Unc51 Family
IPR017406 Serine/threonine-protein kinase Rio3 Ser/Thr_kinase_Rio3 Family
IPR016250 Tyrosine-protein kinase, Fes/Fps type Tyr-prot_kinase_Fes/Fps Family
IPR020691 Ephrin type-A receptor 8 EphrinA_rcpt8 Family
IPR016232 cGMP-dependent protein kinase cGMP-dependent_protein_kinase Family
IPR017400 Elongation factor 2 kinase Elongation_factor_2_kinase Family
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2 Tyr_kinase_non-rcpt_Jak/Tyk2 Family
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type PI3K_Vps34 Family
IPR009220 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein tRNA_threonyl_synthase/kinase Family
IPR016248 Fibroblast growth factor receptor family FGF_rcpt_fam Family
IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, 9/10/11 MAPKKK9/10/11 Family
IPR015785 Mitogen-activated protein (MAP) kinase kinase kinase 10 MAP3K10 Family
IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2 Ser/Thr_kin_STPK_Ulk-1/2 Family
IPR016234 Serine/threonine-protein kinase, Sbk1 Ser/Thr_kinase_Sbk1 Family
IPR016235 Tyrosine/threonine-protein kinase, Cdc2 inhibitor Tyr/Thr_kinase_Cdc2_inhib Family
IPR016241 Serine/threonine-protein kinase YKL171W, predicted Ser/Thr_kin_YKL171w_prd Family
IPR016240 Serine/threonine-protein kinase YKL116C, predicted Ser/Thr_kin_YKL116c_prd Family
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor family Tyr_kinase_CSF1/PDGF_rcpt Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Engh RA Structural aspects of protein kinase control-role of conformational flexibility. 2002 Pharmacol Ther 93 99-111
Walker EH Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. 2000 Mol Cell 6 909-19
Peisach D The crystal structure of choline kinase reveals a eukaryotic protein kinase fold. 2003 Structure 11 703-13
Burk DL Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase. 2001 Biochemistry 40 8756-64

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)