InterPro : IPR006674

Name  HD domain Short Name  HD_domain
Type  Domain Description  The HD domain is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity []. These enzymes appear to be involved in the nucleic acid metabolism, signal transduction and possibly other functions in bacteria, archaea and eukaryotes.The fact that all the highly conserved residues in the HD superfamily are histidines or aspartates suggests that coordination of divalent cations is essential for the activity of these proteins [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR006675 Uncharacterised domain HDIG Uncharacterised_HDIG Domain

0 Contains

7 Found In

Id Name Short Name Type
IPR004811 RelA/SpoT family RelA/Spo_fam Family
IPR017705 Ribonuclease Y Ribonuclease_Y Family
IPR017771 Cyanamide hydratase, HD-type Cyanamide_hydratase_HD Family
IPR006261 Deoxyguanosinetriphosphate triphosphohydrolase dGTP_triP_hydro Family
IPR010043 Protein-PII uridylyltransferase GlnD_Uridyltrans Family
IPR020779 Deoxyguanosinetriphosphate triphosphohydrolase, proteobacteria dGTP_triP_hydro_proteobacteria Family
IPR020873 3'-5' exoribonuclease YhaM 3'-5'_exoribonuclease_YhaM Family

1 Parent Features

Id Name Short Name Type
IPR003607 HD/PDEase domain HD/PDEase_dom Domain

2 Publications

First Author Title Year Journal Volume Pages
Aravind L The HD domain defines a new superfamily of metal-dependent phosphohydrolases. 1998 Trends Biochem Sci 23 469-72
Nagata M Phosphodiesterase activity of CvfA is required for virulence in Staphylococcus aureus. 2008 J Biol Chem 283 2176-84

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)