InterPro : IPR011992

Name  EF-hand domain pair Short Name  EF-hand-dom_pair
Type  Domain Description  This domain consists of a duplication of two EF-hand units, where each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain [, ]. These include: calbindin D9K, S100 proteins such as calcyclin, polcalcin phl p 7 (a calcium-binding pollen allergen), osteonectin, parvalbumin, calmodulin []family of proteins (troponin C, caltractin, cdc4p, myosin essential chain, calcineurin, recoverin, neurocalcin), plasmodial-specific CaII-binding protein Cbp40, penta-EF-Hand proteins [](sorcin, grancalcin, calpain), as well as multidomain proteins such as phosphoinositide-specific phospholipase C, dystrophin, Cb1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



3 Child Features

Id Name Short Name Type
IPR014741 Adaptor protein Cbl, EF hand-like Adaptor_Cbl_EF_hand-like Domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like PLipase_C_EF-hand-like Domain
IPR019577 SPARC/Testican, calcium-binding domain SPARC/Testican_Ca-bd-dom Domain

11 Contains

Id Name Short Name Type
IPR002048 EF-hand domain EF_hand_dom Domain
IPR014837 EF-hand, Ca insensitive EF-hand_Ca_insen Domain
IPR015153 EF-hand domain, type 1 EF-hand_dom_typ1 Domain
IPR015154 EF-hand domain, type 2 EF-hand_dom_typ2 Domain
IPR013567 EF hand associated, type-2 EF_hand_assoc_2 Domain
IPR013566 EF hand associated, type-1 EF_hand_assoc_1 Domain
IPR018247 EF-Hand 1, calcium-binding site EF_Hand_1_Ca_BS Binding_site
IPR001751 S100/Calbindin-D9k, conserved site S100/CaBP-9k_CS Conserved_site
IPR013787 S100/CaBP-9k-type, calcium binding, subdomain S100_Ca-bd_sub Domain
IPR001999 Osteonectin-like, conserved site Osteonectin_CS Conserved_site
IPR013623 NADPH oxidase Respiratory burst NADPH_Ox Domain

10 Found In

Id Name Short Name Type
IPR013801 STAT transcription factor, DNA-binding STAT_TF_DNA-bd Domain
IPR001217 Transcription factor STAT STAT Family
IPR013333 Ryanodine receptor Ryan_recept Family
IPR016344 Dystrophin/utrophin Dystrophin/utrophin Family
IPR016359 SPARC-like protein 1 SPARC-like_p1 Family
IPR008080 Parvalbumin Parvalbumin Family
IPR015754 Calcium binding protein 2 Ca-bd_2 Family
IPR015756 Guanylate cyclase activating protein 2 GCAP-2 Family
IPR015757 Calcineurin B protein Calcineur_B Family
IPR017432 Distrobrevin Distrobrevin Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Ikura M The role of calcium-binding proteins in the control of transcription: structure to function. 2002 Bioessays 24 625-36
Lewit-Bentley A EF-hand calcium-binding proteins. 2000 Curr Opin Struct Biol 10 637-43
Maki M Structures, functions and molecular evolution of the penta-EF-hand Ca2+-binding proteins. 2002 Biochim Biophys Acta 1600 51-60
Vetter SW Novel aspects of calmodulin target recognition and activation. 2003 Eur J Biochem 270 404-14

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)