InterPro : IPR016024

Name  Armadillo-type fold Short Name  ARM-type_fold
Type  Domain Description  This entry represents a structural domain with an armadillo (ARM)-like fold, consisting of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis []. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. Domains and repeats with an ARM-like fold have been found in a number of proteins, including:ARM repeat domain, found in beta-catenins, importins, karyopherin and exportins.HEAT repeat domain, found in protein phosphatase 2a and initiation factor eIF4G.PHAT domain, found in the RNA-binding protein Smaug.Leucine-rich repeat variant, which contain an FeS cluster.Pumilo repeat domain, found in Pumilo protein.Regulatory subunit H of V-type ATPases.PBS lyase HEAT-like repeat.Mo25 protein.MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80.The N-terminal domain of eukaryotic translation initiation factor 3 subunit 12.The C-terminal domain of leukotriene A4 hydrolase.The helical domain of phosphoinositide 3-kinase.The N-terminal fragment of adaptin alpha-C and beta subunits.The proximal leg segment and the linker domain of the clathrin heavy chain.The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. Furthermore, the number of repeats present in the superhelical structure can vary between orthologues, indicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



6 Child Features

Id Name Short Name Type
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain PInositide-3_kin_accessory_dom Domain
IPR003307 W2 domain W2_domain Domain
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal Peptidase_M1_C Domain
IPR011989 Armadillo-like helical ARM-like Domain
IPR016020 Translation initiation factor 3, subunit 12, N-terminal, eukaryotic Transl_init_fac_sub12_N_euk Domain
IPR015327 Smaug, pseudo-HEAT analogous topology Smaug_PHAT Domain

37 Contains

Id Name Short Name Type
IPR003890 MIF4G-like, type 3 MIF4G-like_typ-3 Domain
IPR002015 Proteasome/cyclosome repeat Proteasome/cyclosome_rpt Repeat
IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat Clathrin_H-chain/VPS_repeat Repeat
IPR000225 Armadillo Armadillo Repeat
IPR011987 ATPase, V1 complex, subunit H, C-terminal ATPase_V1-cplx_hsu_C Domain
IPR010508 Domain of unknown function DUF1088 DUF1088 Domain
IPR012993 UME UME Domain
IPR000357 HEAT HEAT Repeat
IPR019451 Domain of unknown function DUF2435 DUF2435 Domain
IPR013180 Beta-catenin-like protein 1, N-terminal CTNNBL1_N Domain
IPR012978 Uncharacterised domain NUC173 Uncharacterised_NUC173 Domain
IPR015348 Clathrin, heavy chain, linker, core motif Clathrin_H-chain_linker_core Domain
IPR007701 Interferon-related developmental regulator, N-terminal Interferon-rel_develop_reg_N Domain
IPR015403 Domain of unknown function DUF1981, Sec7 associated DUF1981_Sec7_assoc Domain
IPR006953 Vesicle tethering protein Uso1/P115-like , head domain Vesicle_Uso1_P115_head Domain
IPR011430 Down-regulated-in-metastasis protein DRIM Domain
IPR013721 STAG STAG Domain
IPR010314 E3 ubiquitin ligase, domain of unknown function DUF913 E3_Ub_ligase_DUF913 Domain
IPR006887 Domain of unknown function DUF625 DUF625 Domain
IPR012582 NUC194 NUC194 Domain
IPR013713 Exportin/Importin, Cse1-like Cse1 Domain
IPR022707 Domain of unknown function DUF3535 DUF3535 Domain
IPR015172 MIF4G-like, type 1 MIF4G-like_typ-1 Domain
IPR015174 MIF4G-like, type 2 MIF4G-like_typ-2 Domain
IPR016021 MIF4-like, type 1/2/3 MIF4-like_typ_1/2/3 Domain
IPR004155 PBS lyase HEAT-like repeat PBS_lyase_HEAT Repeat
IPR021133 HEAT, type 2 HEAT_type_2 Repeat
IPR020839 Stromalin conservative domain SCD Domain
IPR012331 Clathrin, heavy chain, linker Clathrin_H-chain_linker Domain
IPR007205 Protein HGH1 N-terminal Protein_HGH1_N Domain

16 Found In

Id Name Short Name Type
IPR008383 Apoptosis inhibitory 5 API5 Family
IPR016643 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit 26S_Psome_Rpn1 Family
IPR013878 Mo25-like Mo25 Family
IPR004908 ATPase, V1 complex, subunit H ATPase_V1-cplx_hsu Family
IPR016528 Vacuolar protein sorting-associated protein 11 VPS11 Family
IPR016460 Coatomer beta subunit (COPB1) COPB1 Family
IPR004083 Regulatory associated protein of TOR Raptor Family
IPR012502 Wings apart-like, metazoan/plants WAPL_metazoan_plants Family
IPR000091 Huntingtin Huntingtin Family
IPR003913 Tuberin Tuberin Family
IPR014825 DNA alkylation repair enzyme DNA_alkylation Family
IPR016341 Clathrin, heavy chain Clathrin_heavy_chain Family
IPR012371 Condensin-2 complex subunit D3 NCAPD3 Family
IPR016902 Vacuolar protein sorting-associated protein 41 VPS41 Family
IPR016441 Uncharacterised conserved protein UCP005250 UCP005250 Family
IPR017212 Clathrin, heavy chain-related Clathrin_heavy-chain-rel Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Groves MR Topological characteristics of helical repeat proteins. 1999 Curr Opin Struct Biol 9 383-9
Andrade MA Protein repeats: structures, functions, and evolution. 2001 J Struct Biol 134 117-31

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)