InterPro : IPR000330

Name  SNF2-related Short Name  SNF2_N
Type  Domain Description  This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1) [, ]. SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.Proteins that contain this domain appear to be distantly related to theDEAX box helicases, howeverno helicase activity has ever been demonstrated for these proteins.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR014001 Helicase superfamily 1/2, ATP-binding domain Helicase_ATP-bd Domain

0 Found In

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Eisen JA Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. 1995 Nucleic Acids Res 23 2715-23
Linder B The SNF2 domain protein family in higher vertebrates displays dynamic expression patterns in Xenopus laevis embryos. 2004 Gene 326 59-66

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)