InterPro : IPR011701

Name  Major facilitator superfamily Short Name  MFS
Type  Family Description  Among the different families of transporter, only two occur ubiquitously in all classifications of organisms. These are the ATP-Binding Cassette (ABC) superfamily and the Major Facilitator Superfamily (MFS). The MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients [, ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



36 Child Features

Id Name Short Name Type
IPR027197 Solute carrier family 43 member 3 SLC43A3 Family
IPR001958 Tetracycline resistance protein, TetA/multidrug resistance protein MdtG Tet-R_TetA/multi-R_MdtG Family
IPR000849 Sugar phosphate transporter Sugar_P_transporter Family
IPR004742 Sialic acid transporter SA_transporter Family
IPR022324 Bacilysin exporter BacE, putative Bacilysin_exporter_BacE_put Family
IPR004734 Multidrug resistance protein Multidrug-R Family
IPR004737 Nitrate transporter NO3_transporter Family
IPR004744 D-galactonate transporter Dgal_transporter Family
IPR004745 Na-dependent inorganic phosphate cotransporter Pi_cotranspt Family
IPR004743 Monocarboxylate transporter Monocarb_transpt Family
IPR004741 Oxalate/formate antiporter family transporter Oxa_For_antiport_fam_transptr Family
IPR004748 Polyol permease Polyol_permease Family
IPR004746 Major facilitator superfamily, aromatic acid:H+ symporter family MFS_AAHS Family
IPR004747 Cyanate transport system protein Cyan_transport Family
IPR004751 Drug antiporter protein Drug_antiport Family
IPR004752 AmpG-like permease/Acetyl-coenzyme A transporter 1 AmpG_permease/AT-1 Family
IPR004750 Sugar efflux Sugar_efflux Family
IPR001411 Tetracycline resistance protein TetB/drug resistance transporter Tet-R_TetB/Drug-R_transptr Family
IPR014090 Siderophore transporter, RhtX/FptXfamily Siderophore_transpt_RhtX/FptX Family
IPR026355 Oxalate/formate antiporter Oxa/Form_antiport Family
IPR004812 Drug resistance transporter Bcr/CmlA subfamily Efflux_drug-R_Bcr/CmlA Family
IPR012707 4-hydroxyphenylacetate permease HPA_permease Family
IPR022308 Synaptic vesicle protein SV2 SV2 Family
IPR022855 Multidrug resistance protein MdtH Multidrug-R_MdtH Family
IPR017373 Sodium-dependent phosphate transport protein 4 , predicted Na-dep_P-transpt_4_prd Family
IPR005275 L-fucose permease FucP Lfuc_permease_FucP Family
IPR005277 Uncharacterised protein family, Major Facilitator Superfamily MSF4 Uncharacterised_MSF4 Family
IPR027201 Large neutral amino acids transporter small subunit 4 LAT4 Family
IPR005964 Bacterial glucose/galactose transporter Glc/Gal_transptr_bac Family
IPR023008 Uncharacterised protein family UPF0226, major facilitator superfamily UPF0226_MFS Family

2 Contains

Id Name Short Name Type
IPR005829 Sugar transporter, conserved site Sugar_transporter_CS Conserved_site
IPR021159 Glycerate/sugar phosphate transporter, conserved site Sugar-P_transporter_CS Conserved_site

0 Found In

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Pao SS Major facilitator superfamily. 1998 Microbiol Mol Biol Rev 62 1-34
Walmsley AR Sugar transporters from bacteria, parasites and mammals: structure-activity relationships. 1998 Trends Biochem Sci 23 476-81

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)