InterPro : IPR012337

Name  Ribonuclease H-like domain Short Name  RNaseH-like_dom
Type  Domain Description  The catalytic domain of several polynucleotidyl transferases share a similar structure, consisting of a 3-layer alpha/beta/alpha fold that contains mixed beta sheets, suggesting that they share a similar mechanism of catalysis. Polynucleotidyl transferases containing this domain include ribonuclease H class I (RNase HI) and class II (RNase HII), HIV RNase (reverse transcriptase domain), retroviral integrase (catalytic domain), Mu transposase (core domain), transposase inhibitor Tn5 (containing additional all-alpha subdomains), DnaQ-like 3'-5' exonucleases (exonuclease domains), RuvC resolvase, and mitochondrial resolvase ydc2 (catalytic domain) [, , ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



12 Child Features

Id Name Short Name Type
IPR001584 Integrase, catalytic core Integrase_cat-core Domain
IPR002156 Ribonuclease H domain RNaseH_domain Domain
IPR003165 Stem cell self-renewal protein Piwi Piwi Domain
IPR013520 Exonuclease, RNase T/DNA polymerase III Exonuclease_RNaseT/DNA_pol3 Domain
IPR002562 3'-5' exonuclease domain 3'-5'_exonuclease_dom Domain
IPR024567 Ribonuclease HII/HIII domain RNase_HII/HIII_dom Domain
IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain DNA-dir_DNA_pol_B_exonuc Domain
IPR006641 YqgF/RNase H-like domain YqgF/RNaseH-like_dom Domain
IPR004189 Bacteriophage Mu, transposase Phage_Mu_transposase Domain
IPR015361 Taq polymerase, thermostable, exonuclease region Taq_pol_thermo_exonuc Domain
IPR015242 Mitochondrial resolvase Ydc2, catalytic Ydc2_cat Domain
IPR019288 Predicted 3'-5' exonuclease, PolB-like 3'-5'_exonuclease_PolB-like Domain

9 Contains

Id Name Short Name Type
IPR006641 YqgF/RNase H-like domain YqgF/RNaseH-like_dom Domain
IPR001598 Transposase, IS30, conserved site Transposase_IS30_CS Conserved_site
IPR014736 Transposase, Tn5-like, core Transposase_Tn5-like_core Domain
IPR020563 Crossover junction endodeoxyribonuclease RuvC, magnesium-binding site X-over_junc_endoDNase_Mg_BS Binding_site
IPR014735 Transposase, Tn5-like, N-terminal Transposase_Tn5-like_N Domain
IPR014737 Transposase, Tn5-like, C-terminal Transposase_Tn5-like_C Domain
IPR003201 Transposase Tn5, dimerisation Transposase_Tn5 Domain
IPR013617 DNA-directed DNA polymerase, family B, viral insert domain DNA-dir_DNA_pol_B_vir_insert Domain
IPR013620 Exonuclease C-terminal Exonuc_X-T_C Domain

13 Found In

Id Name Short Name Type
IPR002297 DNA-directed DNA-polymerase, family A, mitochondria DNA-dir_DNA_pol_A_mt Family
IPR006172 DNA-directed DNA polymerase, family B DNA-dir_DNA_pol_B Family
IPR002298 DNA polymerase A DNA_polymerase_A Family
IPR018320 DNA polymerase 1 DNA_polymerase_1 Family
IPR006310 DnaQ exonuclease/DinG helicase, predicted DnaQ_DinG Family
IPR006308 DNA polymerase III, alpha subunit, Gram-positive type PolC_gram_pos Family
IPR016265 DNA-directed DNA polymerase, family A, mitochondria, subgroup DNA-dir_DNA_pol_A_mt_sub Family
IPR014636 RNase H, phosphoglycerate mutase domain-containing RNaseH/PGlycerate_mutase Family
IPR017067 Ribonuclease H1, eukaryote RNase_H1_euk Family
IPR006292 Ribonuclease D RNase_D Family
IPR014382 DNA-directed DNA polymerase, family B, adenovirus DNA-dir_DNA_pol_B_adenovir Family
IPR015833 DNA-directed DNA polymerase, family B, mitochondrial linear plasmid DNA-dir_DNA_pol_B_mt_lin_plsmd Family
IPR017290 Ribonuclease H, bacteria RNase_H_bac Family

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Chattopadhyay D Crystallographic analyses of an active HIV-1 ribonuclease H domain show structural features that distinguish it from the inactive form. 1993 Acta Crystallogr D Biol Crystallogr 49 423-7
Rice P Retroviral integrases and their cousins. 1996 Curr Opin Struct Biol 6 76-83
Sigala B Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance. 2003 Eur J Biochem 270 2837-47

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)