InterPro : IPR027417

Name  P-loop containing nucleoside triphosphate hydrolase Short Name  P-loop_NTPase
Type  Domain Description  The P-loop NTPase fold is the most prevalent domain of the several distinctnucleotide-binding protein folds.The most common reaction catalysed by enzymes of the P-loop NTPase fold is the hydrolysis of the beta-gamma phosphate bond of a bound nucleoside triphosphate (NTP). The energy from NTP hydrolysis is typically utilised to induce conformational changes in other molecules, which constitutes the basis of the biological functions of most P-loop NTPases. P-loop NTPases show substantial substrate preference for either ATP or GTP []. P-loop NTPases are characterised by two conserved sequence signatures, theWalker A The Walker A motif (the P-loop proper) and Walker B motifs which bind, respectively, the beta and gamma phosphate moieties of the bound NTP, and a Mg2+ cation [].P-loop ATPase domains belong to one of the two major divisions. The kinase-GTPase (KG) division includes the kinases and GTPases, and the ASCE division, characterised by an additional strand in the core sheet, which is locatedbetween the P-loop strand and the Walker B strand. Most members of the ASCE division utilise ATP and members of this group include AAA+, ABC, PilT, HerA-FtsK, superfamily 1/2 (SF1/2) helicases, and the RecA/ATP-synthase superfamilies of ATPases, etc [, ].
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

Other

13 Child Features

Id Name Short Name Type
IPR001609 Myosin head, motor domain Myosin_head_motor_dom Domain
IPR003593 AAA+ ATPase domain AAA+_ATPase Domain
IPR029007 MobB-type P-loop domain MobB-typ_P-loop Domain
IPR030381 Dynamin-type guanine nucleotide-binding (G) domain G_DYNAMIN_dom Domain
IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain G_GB1_RHD3_dom Domain
IPR030378 Circularly permuted (CP)-type guanine nucleotide-binding (G) domain G_CP_dom Domain
IPR030394 HflX-type guanine nucleotide-binding (G) domain G_HFLX_dom Domain
IPR006703 AIG1-type guanine nucleotide-binding (G) domain G_AIG1 Domain
IPR030393 EngB-type guanine nucleotide-binding (G) domain G_ENGB_dom Domain
IPR030385 IRG-type guanine nucleotide-binding (G) domain G_IRG_dom Domain
IPR030383 Very large inducible GTPASE (VLIG)-type guanine nucleotide-binding (G) domain G_VLIG_dom Domain
IPR030389 FeoB-type guanine nucleotide-binding (G) domain G_FEOB_dom Domain
IPR030388 Era-type guanine nucleotide-binding (G) domain G_ERA_dom Domain

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0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Walker JE Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. 1982 EMBO J 1 945-51
Leipe DD Classification and evolution of P-loop GTPases and related ATPases. 2002 J Mol Biol 317 41-72
Leipe DD STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer. 2004 J Mol Biol 343 1-28
Leipe DD Evolution and classification of P-loop kinases and related proteins. 2003 J Mol Biol 333 781-815



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)