InterPro : IPR018499

Name  Tetraspanin/Peripherin Short Name  Tetraspanin/Peripherin
Type  Family Description  Tetraspanins are a distinct family of proteins, containing four transmembrane domains: a small outer loop (EC1), a larger outer loop (EC2), a small inner loop (IL) and short cytoplasmic tails. They contain characteristic structural features, including 4-6 conserved extracellular cysteine residues, and polar residues within transmembrane domains. A fundamental role of tetraspanins appears to be organizing other proteins into a network of multimolecular membrane microdomains, sometimes called the `tetraspanin web'. This entry represents tetraspanin proteins. It also recognises a number of peripherins. These are related retinal-specific memebers of the tetraspanin family which are located at the rims of the photoreceptor disks, where they may act jointly in disk morphogenesis [].
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Proteins

InterPro protein domain ID --> Contigs

Genes

GO Displayer

 

Other

2 Child Features

Id Name Short Name Type
IPR000301 Tetraspanin Tetraspanin Family
IPR000830 Peripherin/rom-1 Peripherin/rom-1 Family

3 Contains

Id Name Short Name Type
IPR008952 Tetraspanin, EC2 domain Tetraspanin_EC2 Domain
IPR018503 Tetraspanin, conserved site Tetraspanin_CS Conserved_site
IPR018498 Peripherin/rom-1, conserved site Peripherin/rom-1_CS Conserved_site

0 Found In

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Bascom RA Cloning of the cDNA for a novel photoreceptor membrane protein (rom-1) identifies a disk rim protein family implicated in human retinopathies. 1992 Neuron 8 1171-84



To cite PlanMine, please refer to the following publication:

Brandl, H., Moon, H., Vila-Farré, M., Liu, S.-Y., Henry, I., & Rink, J. C.
PlanMine - a mineable resource of planarian biology and biodiversity.
Nucleic Acids Research, gkv1148. doi:10.1093/nar/gkv1148 (2015)