InterPro : IPR030288

Name  Transient receptor potential ankyrin 1 channel Short Name  TRPA1/painless
Type  Family Description  This entry includes transient receptor potential ankyrin 1 channel (TRPA1, also known as Anktm1) from mammals and its homologues from insects and worms. TRPA1 is a nonselective cation channel permeable to Ca(2+), Na(+), and K(+) []. TRPA1 belongs to the TRP family of ion channels. It contains multiple ankyrin repeats in its N-terminal. In mammals, TRPA1 is widely expressed in neuronal cells (e.g. sensory dorsal root and trigeminal ganglia neurons) and in non-neuronal cells (e.g. epithelial cells, hair cells). It plays an important part in acute and chronic (neuropathic) pain and inflammation []. In Drosophila melanogaster, there are three mammalian TRPA1 homologues, protein painless, protein pyrexia and TRPA1. Protein painless is involved in detection of pain sensation due to high temperature [], protein pyrexia is involved in protection from high temperature stress [], while Drosophila TRPA1 is essential for thermotaxis by sensing environmental temperature [].In C. elegans, TRPA1 contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. However, it has no apparent role in thermosensory or chemosensory behaviours [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

0 Parent Features

6 Publications

First Author Title Year Journal Volume Pages
Tracey WD Jr painless, a Drosophila gene essential for nociception. 2003 Cell 113 261-73
Zygmunt PM TRPA1. 2014 Handb Exp Pharmacol 222 583-630
Kindt KS Caenorhabditis elegans TRPA-1 functions in mechanosensation. 2007 Nat Neurosci 10 568-77
Nilius B The transient receptor potential channel TRPA1: from gene to pathophysiology. 2012 Pflugers Arch 464 425-58
Rosenzweig M The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. 2005 Genes Dev 19 419-24
Lee Y Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster. 2005 Nat Genet 37 305-10

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Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)