InterPro : IPR029898

Name  Methionine adenosyltransferase 2 subunit beta Short Name  MAT2_B
Type  Family Description  This entry represents the non-catalytic, regulatory beta subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyses the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. S-adenosylmethionine is the principal biological methyl donor []and a key regulator of hepatocyte proliferation, death, and differentiation []. The beta subunit (MAT2B) regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR005913 dTDP-4-dehydrorhamnose reductase family dTDP_dehydrorham_reduct Family

3 Publications

First Author Title Year Journal Volume Pages
LeGros HL Jr Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). 2000 J Biol Chem 275 2359-66
Mato JM Role of S-adenosyl-L-methionine in liver health and injury. 2007 Hepatology 45 1306-12
Kera Y Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus. 2013 J Biol Chem 288 13592-601

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)