InterPro : IPR028727

Name  Chromodomain-helicase-DNA-binding protein 5 Short Name  CHD5
Type  Family Description  There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a beta-sheet folded against an alpha-helix that collectively mediates binding to methyl-lysine residues []. This entry represent chromodomain-helicase-DNA-binding protein 5 (CHD5). CHD5 is almost exclusively expresssed in brain and testis, and is required for spermiogenesis and chromatin condensation []. CHD5 plays a role in the development of the nervous system [, , ]. It has been identified as a tumour suppressor [].
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Proteins

InterPro protein domain ID --> Contigs

 

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6 Publications

First Author Title Year Journal Volume Pages
Stanley FK CHD chromatin remodelling enzymes and the DNA damage response. 2013 Mutat Res 750 31-44
Thompson PM CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system. 2003 Oncogene 22 1002-11
Fujita T CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas. 2008 J Natl Cancer Inst 100 940-9
Zhuang T CHD5 is required for spermiogenesis and chromatin condensation. 2014 Mech Dev 131 35-46
Vestin A The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain. 2013 Gene Expr Patterns 13 482-9
Egan CM CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. 2013 Dev Cell 26 223-36



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)