InterPro : IPR001497

Name  Methylated-DNA-[protein]-cysteine S-methyltransferase, active site Short Name  MethylDNA_cys_MeTrfase_AS
Type  Active_site Description  Synonym(s): 6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferase, Methylated-DNA-[protein]-cysteine S-methyltransferase.This entry represents the active site of 6-O-methylguanine-DNA methyltransferases.The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase (). The major mutagenic and carcinogenic effect of methylating agents in DNA is the formation of O6-alkylguanine. The alkyl group at the O-6 position is transferred to a cysteine residue in the enzyme []. This is a suicide reaction since the enzyme is irreversibly inactivatedand the methylated protein accumulates as a dead-end product. Most, but notall of the methyltransferases are also able to repair O-4-methylthymine. DNA-[protein]-cysteine S-methyltransferases are widely distributed and are found in various prokaryotic and eukaryotic sources [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding MethylDNA_cys_MeTrfase_DNA-bd Domain
IPR016221 Bifunctional regulatory protein Ada Bifunct_regulatory_prot_Ada Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Lindahl T Regulation and expression of the adaptive response to alkylating agents. 1988 Annu Rev Biochem 57 133-57
Rafferty JA Isolation and partial characterisation of a Chinese hamster O6-alkylguanine-DNA alkyltransferase cDNA. 1992 Nucleic Acids Res 20 1891-5



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)