InterPro : IPR013829

Name  Haemagglutinin, stalk Short Name  Hemagglutn_stalk
Type  Domain Description  Haemagglutinin (HA) is one of two main surface fusion glycoproteins embedded in the envelope of influenza viruses, the other being neuraminidase (NA). There are sixteen known HA subtypes (H1-H16) and nine NA subtypes (N1-N9), which together are used to classify influenza viruses (e.g. H5N1). The antigenic variations in HA and NA enable the virus to evade host antibodies made to previous influenza strains, accounting for recurrent influenza epidemics []. The HA glycoprotein is present in the viral membrane as a single polypeptide (HA0), which must be cleaved by the host's trypsin-like proteases to produce two peptides (HA1 and HA2) in order for the virus to be infectious. Once HA0 is cleaved, the newly exposed N-terminal of the HA2 peptide then acts to fuse the viral envelope to the cellular membrane of the host cell, which allows the viral negative-stranded RNA to infect the host cell. The type of host protease can influence the infectivity and pathogenicity of the virus.The haemagglutinin glycoprotein is a trimer containing three structurally distinct regions: a globular head consisting of anti-parallel beta-sheets that form a beta-sandwich with a jelly-roll fold (contains the receptor binding site and the HA1/HA2 cleavage site); a triple-stranded, coiled-coil, alpha-helical stalk; and a globular foot composed of anti-parallel beta-sheets [, ]. Each monomer consists of an intact HA0 polypeptide with the HA1 and HA2 regions linked by disulphide bonds. The N terminus of HA1 provides the central strand in the 5-stranded globular foot, while the rest of the HA1 chain makes its way to the 8-stranded globular head. HA2 provides two alpha helices, which form part of the triple-stranded coiled-coil that stabilises the trimer, its C terminus providing the remaining strands of the 5-stranded globular foot.This entry represents the stalk region of the intact haemagglutinin HA0 molecule.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR014831 Haemagglutinin stalk, influenza C Hemagglutn_stalk_influenz-C Domain

0 Contains

4 Found In

Id Name Short Name Type
IPR000149 Haemagglutinin, influenzavirus A Hemagglutn_influenz_A Family
IPR001364 Haemagglutinin, influenzavirus A/B Hemagglutn_influenz_A/B Family
IPR000386 Haemagglutinin, influenzavirus B Hemagglutn_influenz_B Family
IPR008980 Viral capsid/haemagglutinin protein Capsid_hemagglutn Domain

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Stevens J Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. 2006 Science 312 404-10
Vaccaro L Plasticity of influenza haemagglutinin fusion peptides and their interaction with lipid bilayers. 2005 Biophys J 88 25-36
Fislová T The factors of virulence of influenza a virus. 2005 Acta Virol 49 147-57

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)