InterPro : IPR008341

Name  Dishevelled-2 Short Name  DVL2
Type  Family Description  Dishevelled (Dsh) proteins possess three conserved domains: an amino-terminal DIX domain, a central PDZ and a carboxyl-terminal DEP domain. They acts downstream of Fz receptors in the Wnt signalling pathway, which controls a variety of developmental and homeostatic events []. Dishevelled-2 (DVL-2) participates in Wnt signalling by binding to the cytoplasmic C terminus of frizzled family members and transducing the Wnt signal to down-stream effectors [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

5 Contains

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR001158 DIX domain DIX Domain
IPR001478 PDZ domain PDZ Domain
IPR000591 DEP domain DEP_dom Domain
IPR003351 Dishevelled protein domain Dishevelled_protein_dom Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR008339 Dishevelled family Dishevelled_fam Family

2 Publications

First Author Title Year Journal Volume Pages
Pan WJ Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1. 2004 Cell Res 14 324-30
Zhang Y Inhibition of Wnt signaling by Dishevelled PDZ peptides. 2009 Nat Chem Biol 5 217-9



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)