InterPro : IPR013021

Name  Myo-inositol-1-phosphate synthase, GAPDH-like Short Name  Myo-inos-1-P_Synthase_GAPDH
Type  Domain Description  This is a region of myo-inositol-1-phosphate synthases that is related to the glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain. 1L-myo-Inositol-1-phosphate synthase () catalyzes the conversion of D-glucose 6-phosphate to 1L-myo-inositol-1-phosphate, the first committed step in the production of all inositol-containing compounds, including phospholipids, either directly or by salvage. The enzyme exists in a cytoplasmic form in a wide range of plants, animals, and fungi. It has also been detected in several bacteria and a chloroplast form is observed in alga and higher plants. Inositol phosphates play an important role in signal transduction.In Saccharomyces cerevisiae(Baker's yeast), the transcriptional regulation of the INO1 gene has been studied in detail []and its expression is sensitive to the availability of phospholipid precursors as well as growth phase. The regulation of the structural gene encoding 1L-myo-inositol-1-phosphate synthase has also been analyzed at the transcriptional level in the aquatic angiosperm, Spirodela polyrrhiza(Giant duckweed) and the halophyte, Mesembryanthemum crystallinum(Common ice plant) [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

3 Found In

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR002587 Myo-inositol-1-phosphate synthase Myo-inos-1-P_Synthase Family
IPR017815 Myo-inositol 1-phosphate synthase, actinobacteria Myo-inos-1-P_Synthase_actino Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages
Klig LS Comparison of INO1 gene sequences and products in Candida albicans and Saccharomyces cerevisiae. 1994 Yeast 10 789-800
Majumder AL 1L-myo-inositol-1-phosphate synthase. 1997 Biochim Biophys Acta 1348 245-56

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)