InterPro : IPR004811

Name  RelA/SpoT family Short Name  RelA/Spo_fam
Type  Family Description  The functions of Escherichia coliRelA and SpoT differ somewhat. RelA () produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT is a bifunctional enzyme; it degrades ppGpp, but can also act as a ppGpp synthetase. The two proteins are strongly similar. In many species, a single homologue to SpoT and RelA appears responsible for both ppGpp synthesis and ppGpp degradation [, ]. (p)ppGpp (alarmone) is a regulatory metabolite of the stringent response, which is characterised by growth arrest and the modulation of gene expression in response to various nutritional stresses [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

4 Contains

Id Name Short Name Type
IPR006674 HD domain HD_domain Domain
IPR004095 TGS TGS Domain
IPR002912 ACT domain ACT_dom Domain
IPR007685 RelA/SpoT RelA_SpoT Domain

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Magnusson LU ppGpp: a global regulator in Escherichia coli. 2005 Trends Microbiol 13 236-42
Wendrich TM Cloning and characterization of a relA/spoT homologue from Bacillus subtilis. 1997 Mol Microbiol 26 65-79
Mittenhuber G Comparative genomics and evolution of genes encoding bacterial (p)ppGpp synthetases/hydrolases (the Rel, RelA and SpoT proteins). 2001 J Mol Microbiol Biotechnol 3 585-600

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)